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Altered structural and functional thalamocortical networks in secondarily generalized extratemporal lobe seizures
Structural and functional abnormalities in the thalamocortical network in primary generalized epilepsies or mesial temporal lobe epilepsy have recently been identified by voxel-wise analyses of neuroimaging. However, evidence is needed regarding the profiles of the thalamocortical network in patient...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133650/ https://www.ncbi.nlm.nih.gov/pubmed/27942447 http://dx.doi.org/10.1016/j.nicl.2016.11.010 |
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author | Peng, Syu-Jyun Hsin, Yue-Loong |
author_facet | Peng, Syu-Jyun Hsin, Yue-Loong |
author_sort | Peng, Syu-Jyun |
collection | PubMed |
description | Structural and functional abnormalities in the thalamocortical network in primary generalized epilepsies or mesial temporal lobe epilepsy have recently been identified by voxel-wise analyses of neuroimaging. However, evidence is needed regarding the profiles of the thalamocortical network in patients with secondarily generalized seizures from focal neocortical sources. We used high-resolution T1-weighted, diffusion-tensor and resting-state functional MR imaging (rs-fMRI) to examine 16 patients with secondarily generalized extratemporal lobe seizures and 16 healthy controls. All the patients were medically effective and MRI-negative. Using whole brain voxel-based morphometry (VBM) to compare the patients with the normal controls, we observed significantly decreased gray matter (GM) density in the thalamus and 3 frontal gyri and significantly reduced white matter (WM) fractional anisotropy (FA) in the bilateral anterior corona radiata of the patients. Alterations in the thalamocortical functional connectivity with different cortices were identified by the rs-fMRI analysis seeding of the whole thalamus. The prefrontal gyri with the greatest functional connectivity were also traced by seeding a sub-thalamic region that is demarcated in an atlas, in which the thalamic parcellation is based on the WM connectivity to the cortices. This sub-thalamic region anatomically contains the mediodorsal thalamic nucleus where, concordantly, there was a significant decrease in thalamic GM density in the VBM study. In contrast to the negative correlation between the disease duration and reduced thalamic densities and subcortical FA values, the strength of the functional thalamocortical connectivity had a paradoxical correlation. Our results conclusively indicate that generalized seizures with a focal cortical source are associated with structural and functional alterations in the thalamocortical network. |
format | Online Article Text |
id | pubmed-5133650 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-51336502016-12-09 Altered structural and functional thalamocortical networks in secondarily generalized extratemporal lobe seizures Peng, Syu-Jyun Hsin, Yue-Loong Neuroimage Clin Regular Article Structural and functional abnormalities in the thalamocortical network in primary generalized epilepsies or mesial temporal lobe epilepsy have recently been identified by voxel-wise analyses of neuroimaging. However, evidence is needed regarding the profiles of the thalamocortical network in patients with secondarily generalized seizures from focal neocortical sources. We used high-resolution T1-weighted, diffusion-tensor and resting-state functional MR imaging (rs-fMRI) to examine 16 patients with secondarily generalized extratemporal lobe seizures and 16 healthy controls. All the patients were medically effective and MRI-negative. Using whole brain voxel-based morphometry (VBM) to compare the patients with the normal controls, we observed significantly decreased gray matter (GM) density in the thalamus and 3 frontal gyri and significantly reduced white matter (WM) fractional anisotropy (FA) in the bilateral anterior corona radiata of the patients. Alterations in the thalamocortical functional connectivity with different cortices were identified by the rs-fMRI analysis seeding of the whole thalamus. The prefrontal gyri with the greatest functional connectivity were also traced by seeding a sub-thalamic region that is demarcated in an atlas, in which the thalamic parcellation is based on the WM connectivity to the cortices. This sub-thalamic region anatomically contains the mediodorsal thalamic nucleus where, concordantly, there was a significant decrease in thalamic GM density in the VBM study. In contrast to the negative correlation between the disease duration and reduced thalamic densities and subcortical FA values, the strength of the functional thalamocortical connectivity had a paradoxical correlation. Our results conclusively indicate that generalized seizures with a focal cortical source are associated with structural and functional alterations in the thalamocortical network. Elsevier 2016-11-12 /pmc/articles/PMC5133650/ /pubmed/27942447 http://dx.doi.org/10.1016/j.nicl.2016.11.010 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Regular Article Peng, Syu-Jyun Hsin, Yue-Loong Altered structural and functional thalamocortical networks in secondarily generalized extratemporal lobe seizures |
title | Altered structural and functional thalamocortical networks in secondarily generalized extratemporal lobe seizures |
title_full | Altered structural and functional thalamocortical networks in secondarily generalized extratemporal lobe seizures |
title_fullStr | Altered structural and functional thalamocortical networks in secondarily generalized extratemporal lobe seizures |
title_full_unstemmed | Altered structural and functional thalamocortical networks in secondarily generalized extratemporal lobe seizures |
title_short | Altered structural and functional thalamocortical networks in secondarily generalized extratemporal lobe seizures |
title_sort | altered structural and functional thalamocortical networks in secondarily generalized extratemporal lobe seizures |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133650/ https://www.ncbi.nlm.nih.gov/pubmed/27942447 http://dx.doi.org/10.1016/j.nicl.2016.11.010 |
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