MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment

Rather than targeting tumour cells directly, elements of the tumour microenvironment can be modulated to sensitize tumours to the effects of therapy. Here we report a unique mechanism by which ectopic microRNA-103 can manipulate tumour-associated endothelial cells to enhance tumour cell death. Using...

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Detalles Bibliográficos
Autores principales: Wilson, RaeAnna, Espinosa-Diez, Cristina, Kanner, Nathan, Chatterjee, Namita, Ruhl, Rebecca, Hipfinger, Christina, Advani, Sunil J., Li, Jie, Khan, Omar F., Franovic, Aleksandra, Weis, Sara M., Kumar, Sushil, Coussens, Lisa M., Anderson, Daniel G., Chen, Clark C., Cheresh, David A., Anand, Sudarshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133658/
https://www.ncbi.nlm.nih.gov/pubmed/27886180
http://dx.doi.org/10.1038/ncomms13597

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