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Vascular endothelial growth factor levels and rheumatic diseases of the elderly

BACKGROUND: Increasing vascular endothelial growth factor (VEGF) has been reported in remitting symmetrical seronegative synovitis with pitting edema (RS3PE) syndrome, rheumatoid arthritis (RA), polymyalgia rheumatica (PMR) and giant cell arteritis (GCA). The aim of this study was to compare VEGF le...

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Autores principales: Smets, Perrine, Devauchelle-Pensec, Valérie, Rouzaire, Paul-Olivier, Pereira, Bruno, Andre, Marc, Soubrier, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133736/
https://www.ncbi.nlm.nih.gov/pubmed/27906058
http://dx.doi.org/10.1186/s13075-016-1184-x
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author Smets, Perrine
Devauchelle-Pensec, Valérie
Rouzaire, Paul-Olivier
Pereira, Bruno
Andre, Marc
Soubrier, Martin
author_facet Smets, Perrine
Devauchelle-Pensec, Valérie
Rouzaire, Paul-Olivier
Pereira, Bruno
Andre, Marc
Soubrier, Martin
author_sort Smets, Perrine
collection PubMed
description BACKGROUND: Increasing vascular endothelial growth factor (VEGF) has been reported in remitting symmetrical seronegative synovitis with pitting edema (RS3PE) syndrome, rheumatoid arthritis (RA), polymyalgia rheumatica (PMR) and giant cell arteritis (GCA). The aim of this study was to compare VEGF levels in patients over 60 years of age who have RS3PE, RA, PMR or GCA so as to determine whether elevated VEGF is specific for a rheumatic disease, the inflammation or edema that occurs with these pathological conditions. METHODS: In this retrospective, multicentric study we assessed serum and plasma levels of VEGF in patients over 60 years of age with rheumatic diseases that were either de novo or of recent onset according to the initial clinical presentation, and we compared these patients with a control group. RESULTS: Serum and plasma VEGF levels were determined in 80 patients (5 with RS3PE, 13 with RA, 44 with PMR, and 18 with GCA) and 37 controls. Edema occurred in five patients with RS3PE, four with RA, and one with PMR, but not patients with GCA. Serum VEGF levels were significantly higher in individuals with rheumatic diseases (849 (405.5–1235.5) pg/ml) relative to the controls (484 (302–555) pg/ml) (p < 0.001). There were no significant differences between patients with RS3PE, RA, PMR, or GCA in terms of the VEGF serum levels (p = 0.60) or plasma levels (p = 0.57). Similarly, the occurrence of edema did not correlate with VEGF levels. CONCLUSION: VEGF increases in rheumatic diseases compared to a control group. This was not associated with specific rheumatic diseases or with edematous rheumatic diseases.
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spelling pubmed-51337362016-12-15 Vascular endothelial growth factor levels and rheumatic diseases of the elderly Smets, Perrine Devauchelle-Pensec, Valérie Rouzaire, Paul-Olivier Pereira, Bruno Andre, Marc Soubrier, Martin Arthritis Res Ther Research Article BACKGROUND: Increasing vascular endothelial growth factor (VEGF) has been reported in remitting symmetrical seronegative synovitis with pitting edema (RS3PE) syndrome, rheumatoid arthritis (RA), polymyalgia rheumatica (PMR) and giant cell arteritis (GCA). The aim of this study was to compare VEGF levels in patients over 60 years of age who have RS3PE, RA, PMR or GCA so as to determine whether elevated VEGF is specific for a rheumatic disease, the inflammation or edema that occurs with these pathological conditions. METHODS: In this retrospective, multicentric study we assessed serum and plasma levels of VEGF in patients over 60 years of age with rheumatic diseases that were either de novo or of recent onset according to the initial clinical presentation, and we compared these patients with a control group. RESULTS: Serum and plasma VEGF levels were determined in 80 patients (5 with RS3PE, 13 with RA, 44 with PMR, and 18 with GCA) and 37 controls. Edema occurred in five patients with RS3PE, four with RA, and one with PMR, but not patients with GCA. Serum VEGF levels were significantly higher in individuals with rheumatic diseases (849 (405.5–1235.5) pg/ml) relative to the controls (484 (302–555) pg/ml) (p < 0.001). There were no significant differences between patients with RS3PE, RA, PMR, or GCA in terms of the VEGF serum levels (p = 0.60) or plasma levels (p = 0.57). Similarly, the occurrence of edema did not correlate with VEGF levels. CONCLUSION: VEGF increases in rheumatic diseases compared to a control group. This was not associated with specific rheumatic diseases or with edematous rheumatic diseases. BioMed Central 2016-12-01 2016 /pmc/articles/PMC5133736/ /pubmed/27906058 http://dx.doi.org/10.1186/s13075-016-1184-x Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Smets, Perrine
Devauchelle-Pensec, Valérie
Rouzaire, Paul-Olivier
Pereira, Bruno
Andre, Marc
Soubrier, Martin
Vascular endothelial growth factor levels and rheumatic diseases of the elderly
title Vascular endothelial growth factor levels and rheumatic diseases of the elderly
title_full Vascular endothelial growth factor levels and rheumatic diseases of the elderly
title_fullStr Vascular endothelial growth factor levels and rheumatic diseases of the elderly
title_full_unstemmed Vascular endothelial growth factor levels and rheumatic diseases of the elderly
title_short Vascular endothelial growth factor levels and rheumatic diseases of the elderly
title_sort vascular endothelial growth factor levels and rheumatic diseases of the elderly
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133736/
https://www.ncbi.nlm.nih.gov/pubmed/27906058
http://dx.doi.org/10.1186/s13075-016-1184-x
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