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Bidirectional Estrogen-Like Effects of Genistein on Murine Experimental Autoimmune Ovarian Disease
This study was to investigate the bidirectional estrogen-like effects of genistein on murine experimental autoimmune ovarian disease (AOD). Female BALB/c mice were induced by immunization with a peptide from murine zona pellucida. The changes of estrous cycle, ovarian histomorphology were measured,...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133855/ https://www.ncbi.nlm.nih.gov/pubmed/27834809 http://dx.doi.org/10.3390/ijms17111855 |
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author | Ding, Qiao Wang, Yuxiao Li, Na Zhu, Kexue Hu, Jielun Wang, Sunan Zhu, Fan Nie, Shaoping |
author_facet | Ding, Qiao Wang, Yuxiao Li, Na Zhu, Kexue Hu, Jielun Wang, Sunan Zhu, Fan Nie, Shaoping |
author_sort | Ding, Qiao |
collection | PubMed |
description | This study was to investigate the bidirectional estrogen-like effects of genistein on murine experimental autoimmune ovarian disease (AOD). Female BALB/c mice were induced by immunization with a peptide from murine zona pellucida. The changes of estrous cycle, ovarian histomorphology were measured, and the levels of serum sex hormone were analyzed using radioimmunoassay. Proliferative responses of the ovary were also determined by immunohistochemistry. Administration of 25 or 45 mg/kg body weight genistein enhanced ovary development with changes in serum sex hormone levels and proliferative responses. Meanwhile, the proportions of growing and mature follicles increased and the incidence of autoimmune oophoritis decreased, which exhibited normal ovarian morphology in administration of 25 or 45 mg/kg body weight genistein, while a lower dose (5 mg/kg body weight genistein) produced the opposite effect. These findings suggest that genistein exerts bidirectional estrogen-like effects on murine experimental AOD, while a high dose (45 mg/kg body weight) of genistein may suppress AOD. |
format | Online Article Text |
id | pubmed-5133855 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-51338552016-12-12 Bidirectional Estrogen-Like Effects of Genistein on Murine Experimental Autoimmune Ovarian Disease Ding, Qiao Wang, Yuxiao Li, Na Zhu, Kexue Hu, Jielun Wang, Sunan Zhu, Fan Nie, Shaoping Int J Mol Sci Article This study was to investigate the bidirectional estrogen-like effects of genistein on murine experimental autoimmune ovarian disease (AOD). Female BALB/c mice were induced by immunization with a peptide from murine zona pellucida. The changes of estrous cycle, ovarian histomorphology were measured, and the levels of serum sex hormone were analyzed using radioimmunoassay. Proliferative responses of the ovary were also determined by immunohistochemistry. Administration of 25 or 45 mg/kg body weight genistein enhanced ovary development with changes in serum sex hormone levels and proliferative responses. Meanwhile, the proportions of growing and mature follicles increased and the incidence of autoimmune oophoritis decreased, which exhibited normal ovarian morphology in administration of 25 or 45 mg/kg body weight genistein, while a lower dose (5 mg/kg body weight genistein) produced the opposite effect. These findings suggest that genistein exerts bidirectional estrogen-like effects on murine experimental AOD, while a high dose (45 mg/kg body weight) of genistein may suppress AOD. MDPI 2016-11-08 /pmc/articles/PMC5133855/ /pubmed/27834809 http://dx.doi.org/10.3390/ijms17111855 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ding, Qiao Wang, Yuxiao Li, Na Zhu, Kexue Hu, Jielun Wang, Sunan Zhu, Fan Nie, Shaoping Bidirectional Estrogen-Like Effects of Genistein on Murine Experimental Autoimmune Ovarian Disease |
title | Bidirectional Estrogen-Like Effects of Genistein on Murine Experimental Autoimmune Ovarian Disease |
title_full | Bidirectional Estrogen-Like Effects of Genistein on Murine Experimental Autoimmune Ovarian Disease |
title_fullStr | Bidirectional Estrogen-Like Effects of Genistein on Murine Experimental Autoimmune Ovarian Disease |
title_full_unstemmed | Bidirectional Estrogen-Like Effects of Genistein on Murine Experimental Autoimmune Ovarian Disease |
title_short | Bidirectional Estrogen-Like Effects of Genistein on Murine Experimental Autoimmune Ovarian Disease |
title_sort | bidirectional estrogen-like effects of genistein on murine experimental autoimmune ovarian disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133855/ https://www.ncbi.nlm.nih.gov/pubmed/27834809 http://dx.doi.org/10.3390/ijms17111855 |
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