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Characterizing Non-Tuberculous Mycobacteria Infection in Bronchiectasis

Chronic airway infection is a key aspect of the pathogenesis of bronchiectasis. A growing interest has been raised on non-tuberculous mycobacteria (NTM) infection. We aimed at describing the clinical characteristics, diagnostic process, therapeutic options and outcomes of bronchiectasis patients wit...

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Autores principales: Faverio, Paola, Stainer, Anna, Bonaiti, Giulia, Zucchetti, Stefano C., Simonetta, Edoardo, Lapadula, Giuseppe, Marruchella, Almerico, Gori, Andrea, Blasi, Francesco, Codecasa, Luigi, Pesci, Alberto, Chalmers, James D., Loebinger, Michael R., Aliberti, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133910/
https://www.ncbi.nlm.nih.gov/pubmed/27854334
http://dx.doi.org/10.3390/ijms17111913
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author Faverio, Paola
Stainer, Anna
Bonaiti, Giulia
Zucchetti, Stefano C.
Simonetta, Edoardo
Lapadula, Giuseppe
Marruchella, Almerico
Gori, Andrea
Blasi, Francesco
Codecasa, Luigi
Pesci, Alberto
Chalmers, James D.
Loebinger, Michael R.
Aliberti, Stefano
author_facet Faverio, Paola
Stainer, Anna
Bonaiti, Giulia
Zucchetti, Stefano C.
Simonetta, Edoardo
Lapadula, Giuseppe
Marruchella, Almerico
Gori, Andrea
Blasi, Francesco
Codecasa, Luigi
Pesci, Alberto
Chalmers, James D.
Loebinger, Michael R.
Aliberti, Stefano
author_sort Faverio, Paola
collection PubMed
description Chronic airway infection is a key aspect of the pathogenesis of bronchiectasis. A growing interest has been raised on non-tuberculous mycobacteria (NTM) infection. We aimed at describing the clinical characteristics, diagnostic process, therapeutic options and outcomes of bronchiectasis patients with pulmonary NTM (pNTM) disease. This was a prospective, observational study enrolling 261 adult bronchiectasis patients during the stable state at the San Gerardo Hospital, Monza, Italy, from 2012 to 2015. Three groups were identified: pNTM disease; chronic P. aeruginosa infection; chronic infection due to bacteria other than P. aeruginosa. NTM were isolated in 32 (12%) patients, and among them, a diagnosis of pNTM disease was reached in 23 cases. When compared to chronic P. aeruginosa infection, patients with pNTM were more likely to have cylindrical bronchiectasis and a “tree-in-bud” pattern, a history of weight loss, a lower disease severity and a lower number of pulmonary exacerbations. Among pNTM patients who started treatment, 68% showed a radiological improvement, and 37% achieved culture conversion without recurrence, while 21% showed NTM isolation recurrence. NTM isolation seems to be a frequent event in bronchiectasis patients, and few parameters might help to suspect NTM infection. Treatment indications and monitoring still remain an important area for future research.
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spelling pubmed-51339102016-12-12 Characterizing Non-Tuberculous Mycobacteria Infection in Bronchiectasis Faverio, Paola Stainer, Anna Bonaiti, Giulia Zucchetti, Stefano C. Simonetta, Edoardo Lapadula, Giuseppe Marruchella, Almerico Gori, Andrea Blasi, Francesco Codecasa, Luigi Pesci, Alberto Chalmers, James D. Loebinger, Michael R. Aliberti, Stefano Int J Mol Sci Article Chronic airway infection is a key aspect of the pathogenesis of bronchiectasis. A growing interest has been raised on non-tuberculous mycobacteria (NTM) infection. We aimed at describing the clinical characteristics, diagnostic process, therapeutic options and outcomes of bronchiectasis patients with pulmonary NTM (pNTM) disease. This was a prospective, observational study enrolling 261 adult bronchiectasis patients during the stable state at the San Gerardo Hospital, Monza, Italy, from 2012 to 2015. Three groups were identified: pNTM disease; chronic P. aeruginosa infection; chronic infection due to bacteria other than P. aeruginosa. NTM were isolated in 32 (12%) patients, and among them, a diagnosis of pNTM disease was reached in 23 cases. When compared to chronic P. aeruginosa infection, patients with pNTM were more likely to have cylindrical bronchiectasis and a “tree-in-bud” pattern, a history of weight loss, a lower disease severity and a lower number of pulmonary exacerbations. Among pNTM patients who started treatment, 68% showed a radiological improvement, and 37% achieved culture conversion without recurrence, while 21% showed NTM isolation recurrence. NTM isolation seems to be a frequent event in bronchiectasis patients, and few parameters might help to suspect NTM infection. Treatment indications and monitoring still remain an important area for future research. MDPI 2016-11-16 /pmc/articles/PMC5133910/ /pubmed/27854334 http://dx.doi.org/10.3390/ijms17111913 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Faverio, Paola
Stainer, Anna
Bonaiti, Giulia
Zucchetti, Stefano C.
Simonetta, Edoardo
Lapadula, Giuseppe
Marruchella, Almerico
Gori, Andrea
Blasi, Francesco
Codecasa, Luigi
Pesci, Alberto
Chalmers, James D.
Loebinger, Michael R.
Aliberti, Stefano
Characterizing Non-Tuberculous Mycobacteria Infection in Bronchiectasis
title Characterizing Non-Tuberculous Mycobacteria Infection in Bronchiectasis
title_full Characterizing Non-Tuberculous Mycobacteria Infection in Bronchiectasis
title_fullStr Characterizing Non-Tuberculous Mycobacteria Infection in Bronchiectasis
title_full_unstemmed Characterizing Non-Tuberculous Mycobacteria Infection in Bronchiectasis
title_short Characterizing Non-Tuberculous Mycobacteria Infection in Bronchiectasis
title_sort characterizing non-tuberculous mycobacteria infection in bronchiectasis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133910/
https://www.ncbi.nlm.nih.gov/pubmed/27854334
http://dx.doi.org/10.3390/ijms17111913
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