Cargando…

The Role of Deoxycytidine Kinase (dCK) in Radiation-Induced Cell Death

Deoxycytidine kinase (dCK) is a key enzyme in deoxyribonucleoside salvage and the anti-tumor activity for many nucleoside analogs. dCK is activated in response to ionizing radiation (IR)-induced DNA damage and it is phosphorylated on Serine 74 by the Ataxia-Telangiectasia Mutated (ATM) kinase in ord...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhong, Rui, Xin, Rui, Chen, Zongyan, Liang, Nan, Liu, Yang, Ma, Shumei, Liu, Xiaodong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133934/ https://www.ncbi.nlm.nih.gov/pubmed/27879648 http://dx.doi.org/10.3390/ijms17111939

Ejemplares similares

Modulation of deoxycytidine kinase (dCK) and glycogen synthase kinase (GSK-3β) by anti-CD20 (rituximab) and 2-chlorodeoxyadenosine (2-CdA) in human lymphoid malignancies
por: Al-Katib, Ayad M, et al.
Publicado: (2014)

Roles for hENT1 and dCK in gemcitabine sensitivity and malignancy of meningioma
por: Yamamoto, Masahiro, et al.
Publicado: (2021)

dCK negatively regulates the NRF2/ARE axis and ROS production in pancreatic cancer
por: Hu, Qiangsheng, et al.
Publicado: (2018)

ET-7 Roles for hENT1 and dCK in gemcitabine sensitivity and malignancy of meningioma
por: Yamamoto, Masahiro, et al.
Publicado: (2021)

dCK Expression and Gene Polymorphism With Gemcitabine Chemosensitivity in Patients With Pancreatic Ductal Adenocarcinoma: A Strobe-Compliant Observational Study
por: Xiong, Junjie, et al.
Publicado: (2016)

Prognostic effect of hENT1, dCK and HuR expression by morphological type in periampullary adenocarcinoma, including pancreatic cancer
por: Elebro, Jacob, et al.
Publicado: (2016)

Gene expression of hENT1, dCK, CDA, dCMPD and topoisomerase IIα as an indicator of chemotherapy response in AML treated with cytarabine and daunorubicin
por: Kulsoom, Bibi, et al.
Publicado: (2018)

Deoxycytidine kinase regulates the G2/M checkpoint through interaction with cyclin-dependent kinase 1 in response to DNA damage
por: Yang, Chunying, et al.
Publicado: (2012)

Bortezomib prevents cytarabine resistance in MCL, which is characterized by down-regulation of dCK and up-regulation of SPIB resulting in high NF-κB activity
por: Freiburghaus, Catja, et al.
Publicado: (2018)

DCK confers sensitivity of DCTD-positive cancer cells to oxidized methylcytidines
por: Zhao, Ya-Hui, et al.
Publicado: (2022)

Deoxycytidine Kinase Augments ATM-Mediated DNA Repair and Contributes to Radiation Resistance
por: Bunimovich, Yuri L., et al.
Publicado: (2014)

Assistententag des Jungen Forums der DGMKG – DCK 2021
por: Thiem, Daniel
Publicado: (2021)

DCK is an Unfavorable Prognostic Biomarker and Correlated With Immune Infiltrates in Liver Cancer
por: Hu, Shu Fang, et al.
Publicado: (2020)

Role of Genetic Polymorphisms of Deoxycytidine Kinase and Cytidine Deaminase to Predict Risk of Death in Children with Acute Myeloid Leukemia
por: Medina-Sanson, Aurora, et al.
Publicado: (2015)

The Apoptotic Effects of Toosendanin Are Partially Mediated by Activation of Deoxycytidine Kinase in HL-60 Cells
por: Ju, Jianming, et al.
Publicado: (2012)

Emerging role of Protein Kinase CK2 in Tumor immunity
por: Chen, Leichong, et al.
Publicado: (2022)

DCK is a promising prognostic biomarker and correlated with immune infiltrates in hepatocellular carcinoma
por: Song, Danjun, et al.
Publicado: (2020)

Facile method for determination of deoxycytidine kinase activity in biological milieus
por: Hao, Wei-Hua, et al.
Publicado: (2013)

Targeting host deoxycytidine kinase attenuates Staphylococcus aureus virulence
por: Winstel, Volker, et al.
Publicado: (2023)

Ionizing Radiation-Induced Adaptive Response in Fibroblasts under Both Monolayer and 3-Dimensional Conditions
por: Zhao, Yinlong, et al.
Publicado: (2015)

Clinicopathological significance of deoxycytidine kinase expression in esophageal squamous cell carcinoma
por: SHIMADA, YUTAKA, et al.
Publicado: (2013)

Potential Deoxycytidine Kinase Inhibitory Activity of Amaryllidaceae Alkaloids: An In Silico Approach
por: Yousef, Bashir A., et al.
Publicado: (2018)

Iron-Dependent Autophagic Cell Death Induced by Radiation in MDA-MB-231 Breast Cancer Cells
por: Ma, Shumei, et al.
Publicado: (2021)

Genome-Wide CRISPR Screening Identifies DCK and CCNL1 as Genes That Contribute to Gemcitabine Resistance in Pancreatic Cancer
por: Yang, Hai, et al.
Publicado: (2022)

Autophagy inhibition plays the synergetic killing roles with radiation in the multi-drug resistant SKVCR ovarian cancer cells
por: Liang, Bing, et al.
Publicado: (2012)

Danggui Buxue Decoction Sensitizes the Response of Non-Small-Cell Lung Cancer to Gemcitabine via Regulating Deoxycytidine Kinase and P-glycoprotein
por: Sun, Xiyang, et al.
Publicado: (2019)

The Phosphorylation of PDX-1 by Protein Kinase CK2 Is Crucial for Its Stability
por: Klein, Sabrina, et al.
Publicado: (2016)

CK2 and protein kinases of the CK1 superfamily as targets for neurodegenerative disorders
por: Baier, Andrea, et al.
Publicado: (2022)

The Multiple Personalities of the Regulatory Subunit of Protein Kinase CK2: CK2 Dependent and CK2 Independent Roles Reveal a Secret Identity for CK2β
por: Bibby, Ashley C., et al.
Publicado: (2005)

Targeting AHR Increases Pancreatic Cancer Cell Sensitivity to Gemcitabine through the ELAVL1-DCK Pathway
por: Stukas, Darius, et al.
Publicado: (2023)

Targeting Protein Kinases in Blood Cancer: Focusing on CK1α and CK2
por: Spinello, Zaira, et al.
Publicado: (2021)

Radioprotective countermeasures for radiation injury (Review)
por: Liu, Lianchang, et al.
Publicado: (2023)

Structure-Guided Development of Deoxycytidine Kinase Inhibitors with Nanomolar Affinity and Improved Metabolic Stability
por: Nomme, Julian, et al.
Publicado: (2014)

Malaria Protein Kinase CK2 (PfCK2) Shows Novel Mechanisms of Regulation
por: Graciotti, Michele, et al.
Publicado: (2014)

Protein Kinase CK2 in Cancer Energetics
por: Silva-Pavez, Eduardo, et al.
Publicado: (2020)

Role of protein kinase CK2 in antitumor drug resistance
por: Borgo, Christian, et al.
Publicado: (2019)

Evaluation of creatine kinase (CK)-MB to total CK ratio as a diagnostic biomarker for primary tumors and metastasis screening
por: Li, Yan, et al.
Publicado: (2023)

Potent Sensitisation of Cancer Cells to Anticancer Drugs by a Quadruple Mutant of the Human Deoxycytidine Kinase
por: Coulibaly, Safiatou T., et al.
Publicado: (2015)

Deletion Mutants of Human Deoxycytidine Kinase mRNA in Cells Resistant to Antitumor Cytosine Nucleosides
por: Obata, Tohru, et al.
Publicado: (2001)

The Small Yeast GTPase Rho5 and Its Dimeric GEF Dck1/Lmo1 Respond to Glucose Starvation
por: Schmitz, Hans-Peter, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_hta9aiua9okt98bfvgsk0fpf8p