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Neuroprotective Strategies during Cardiac Surgery with Cardiopulmonary Bypass

Aortocoronary bypass or valve surgery usually require cardiac arrest using cardioplegic solutions. Although, in principle, in a number of cases beating heart surgery (so-called off-pump technique) is possible, aortic or valve surgery or correction of congenital heart diseases mostly require cardiopu...

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Autores principales: Salameh, Aida, Dhein, Stefan, Dähnert, Ingo, Klein, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133939/
https://www.ncbi.nlm.nih.gov/pubmed/27879647
http://dx.doi.org/10.3390/ijms17111945
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author Salameh, Aida
Dhein, Stefan
Dähnert, Ingo
Klein, Norbert
author_facet Salameh, Aida
Dhein, Stefan
Dähnert, Ingo
Klein, Norbert
author_sort Salameh, Aida
collection PubMed
description Aortocoronary bypass or valve surgery usually require cardiac arrest using cardioplegic solutions. Although, in principle, in a number of cases beating heart surgery (so-called off-pump technique) is possible, aortic or valve surgery or correction of congenital heart diseases mostly require cardiopulmonary arrest. During this condition, the heart-lung machine also named cardiopulmonary bypass (CPB) has to take over the circulation. It is noteworthy that the invention of a machine bypassing the heart and lungs enabled complex cardiac operations, but possible negative effects of the CPB on other organs, especially the brain, cannot be neglected. Thus, neuroprotection during CPB is still a matter of great interest. In this review, we will describe the impact of CPB on the brain and focus on pharmacological and non-pharmacological strategies to protect the brain.
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spelling pubmed-51339392016-12-12 Neuroprotective Strategies during Cardiac Surgery with Cardiopulmonary Bypass Salameh, Aida Dhein, Stefan Dähnert, Ingo Klein, Norbert Int J Mol Sci Review Aortocoronary bypass or valve surgery usually require cardiac arrest using cardioplegic solutions. Although, in principle, in a number of cases beating heart surgery (so-called off-pump technique) is possible, aortic or valve surgery or correction of congenital heart diseases mostly require cardiopulmonary arrest. During this condition, the heart-lung machine also named cardiopulmonary bypass (CPB) has to take over the circulation. It is noteworthy that the invention of a machine bypassing the heart and lungs enabled complex cardiac operations, but possible negative effects of the CPB on other organs, especially the brain, cannot be neglected. Thus, neuroprotection during CPB is still a matter of great interest. In this review, we will describe the impact of CPB on the brain and focus on pharmacological and non-pharmacological strategies to protect the brain. MDPI 2016-11-21 /pmc/articles/PMC5133939/ /pubmed/27879647 http://dx.doi.org/10.3390/ijms17111945 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Salameh, Aida
Dhein, Stefan
Dähnert, Ingo
Klein, Norbert
Neuroprotective Strategies during Cardiac Surgery with Cardiopulmonary Bypass
title Neuroprotective Strategies during Cardiac Surgery with Cardiopulmonary Bypass
title_full Neuroprotective Strategies during Cardiac Surgery with Cardiopulmonary Bypass
title_fullStr Neuroprotective Strategies during Cardiac Surgery with Cardiopulmonary Bypass
title_full_unstemmed Neuroprotective Strategies during Cardiac Surgery with Cardiopulmonary Bypass
title_short Neuroprotective Strategies during Cardiac Surgery with Cardiopulmonary Bypass
title_sort neuroprotective strategies during cardiac surgery with cardiopulmonary bypass
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133939/
https://www.ncbi.nlm.nih.gov/pubmed/27879647
http://dx.doi.org/10.3390/ijms17111945
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