A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas

Sarcomas comprise a large heterogeneous group of mesenchymal cancers with limited therapeutic options. When treated with standard cytotoxic chemotherapies, many sarcomas fail to respond completely and rapidly become treatment resistant. A major problem in the investigation and treatment of sarcomas...

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Detalles Bibliográficos
Autores principales: Bean, Gregory R, Kremer, Jeff C, Prudner, Bethany C, Schenone, Aaron D, Yao, Juo-Chin, Schultze, Matthew B, Chen, David Y, Tanas, Munir R, Adkins, Douglas R, Bomalaski, John, Rubin, Brian P, Michel, Loren S, Van Tine, Brian A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133958/
https://www.ncbi.nlm.nih.gov/pubmed/27735949
http://dx.doi.org/10.1038/cddis.2016.232

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