Adeno-associated virus-mediated CASQ2 delivery rescues phenotypic alterations in a patient-specific model of recessive catecholaminergic polymorphic ventricular tachycardia

Catecholaminergic Polymorphic Ventricular Tachycardia type 2 (CPVT2) is a highly lethal recessive arrhythmogenic disease caused by mutations in the calsequestrin-2 (CASQ2) gene. We have previously demonstrated that viral transfer of the wild-type (WT) CASQ2 gene prevents the development of CPVT2 in...

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Detalles Bibliográficos
Autores principales: Lodola, Francesco, Morone, Diego, Denegri, Marco, Bongianino, Rossana, Nakahama, Hiroko, Rutigliano, Lucia, Gosetti, Rosanna, Rizzo, Giulia, Vollero, Alessandra, Buonocore, Michelangelo, Napolitano, Carlo, Condorelli, Gianluigi, Priori, Silvia G, Di Pasquale, Elisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133973/
https://www.ncbi.nlm.nih.gov/pubmed/27711080
http://dx.doi.org/10.1038/cddis.2016.304

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