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Bcl-2 proteins bid and bax form a network to permeabilize the mitochondria at the onset of apoptosis
The most critical step in the initiation of apoptosis is the activation of the Bcl-2 family of proteins to oligomerize and permeabilize the outer-mitochondrial membrane (OMM). As this step results in the irreversible release of factors that enhance cellular degradation, it is the point of no return...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133987/ https://www.ncbi.nlm.nih.gov/pubmed/27763642 http://dx.doi.org/10.1038/cddis.2016.320 |