Deep brain stimulation for Parkinson's disease prior to L-dopa treatment: A case report

BACKGROUND: Leva-dopa (L-dopa) is the gold-standard treatment for Parkinson's disease (PD). Deep brain stimulation is generally reserved for patients who become refractory to l-dopa treatment. CASE DESCRIPTION: We present a male patient with a 9-year course of PD who at 53 years of age preferre...

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Detalles Bibliográficos
Autores principales: Servello, Domenico, Saleh, Christian, Bona, Alberto R., Zekaj, Edvin, Zanaboni, Carlotta, Porta, Mauro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134109/
https://www.ncbi.nlm.nih.gov/pubmed/27990314
http://dx.doi.org/10.4103/2152-7806.194064
Descripción
Sumario:BACKGROUND: Leva-dopa (L-dopa) is the gold-standard treatment for Parkinson's disease (PD). Deep brain stimulation is generally reserved for patients who become refractory to l-dopa treatment. CASE DESCRIPTION: We present a male patient with a 9-year course of PD who at 53 years of age preferred deep brain stimulation (DBS) of the subthalamic nucleus over initial l-dopa treatment. The patient argued that he wanted to avoid the serious adverse effects of l-dopa, which would have presented within his time of full professional activity. DBS resulted in significant motor improvement lasting for 6 years without l-dopa treatment. CONCLUSION: Large multicentre-based international trials with long follow-ups are needed to answer the effectiveness of early DBS in PD.

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