Deep brain stimulation for Parkinson's disease prior to L-dopa treatment: A case report

BACKGROUND: Leva-dopa (L-dopa) is the gold-standard treatment for Parkinson's disease (PD). Deep brain stimulation is generally reserved for patients who become refractory to l-dopa treatment. CASE DESCRIPTION: We present a male patient with a 9-year course of PD who at 53 years of age preferre...

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Autores principales: Servello, Domenico, Saleh, Christian, Bona, Alberto R., Zekaj, Edvin, Zanaboni, Carlotta, Porta, Mauro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134109/
https://www.ncbi.nlm.nih.gov/pubmed/27990314
http://dx.doi.org/10.4103/2152-7806.194064
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author Servello, Domenico
Saleh, Christian
Bona, Alberto R.
Zekaj, Edvin
Zanaboni, Carlotta
Porta, Mauro
author_facet Servello, Domenico
Saleh, Christian
Bona, Alberto R.
Zekaj, Edvin
Zanaboni, Carlotta
Porta, Mauro
author_sort Servello, Domenico
collection PubMed
description BACKGROUND: Leva-dopa (L-dopa) is the gold-standard treatment for Parkinson's disease (PD). Deep brain stimulation is generally reserved for patients who become refractory to l-dopa treatment. CASE DESCRIPTION: We present a male patient with a 9-year course of PD who at 53 years of age preferred deep brain stimulation (DBS) of the subthalamic nucleus over initial l-dopa treatment. The patient argued that he wanted to avoid the serious adverse effects of l-dopa, which would have presented within his time of full professional activity. DBS resulted in significant motor improvement lasting for 6 years without l-dopa treatment. CONCLUSION: Large multicentre-based international trials with long follow-ups are needed to answer the effectiveness of early DBS in PD.
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spelling pubmed-51341092016-12-16 Deep brain stimulation for Parkinson's disease prior to L-dopa treatment: A case report Servello, Domenico Saleh, Christian Bona, Alberto R. Zekaj, Edvin Zanaboni, Carlotta Porta, Mauro Surg Neurol Int Case Report BACKGROUND: Leva-dopa (L-dopa) is the gold-standard treatment for Parkinson's disease (PD). Deep brain stimulation is generally reserved for patients who become refractory to l-dopa treatment. CASE DESCRIPTION: We present a male patient with a 9-year course of PD who at 53 years of age preferred deep brain stimulation (DBS) of the subthalamic nucleus over initial l-dopa treatment. The patient argued that he wanted to avoid the serious adverse effects of l-dopa, which would have presented within his time of full professional activity. DBS resulted in significant motor improvement lasting for 6 years without l-dopa treatment. CONCLUSION: Large multicentre-based international trials with long follow-ups are needed to answer the effectiveness of early DBS in PD. Medknow Publications & Media Pvt Ltd 2016-11-14 /pmc/articles/PMC5134109/ /pubmed/27990314 http://dx.doi.org/10.4103/2152-7806.194064 Text en Copyright: © 2016 Surgical Neurology International http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Servello, Domenico
Saleh, Christian
Bona, Alberto R.
Zekaj, Edvin
Zanaboni, Carlotta
Porta, Mauro
Deep brain stimulation for Parkinson's disease prior to L-dopa treatment: A case report
title Deep brain stimulation for Parkinson's disease prior to L-dopa treatment: A case report
title_full Deep brain stimulation for Parkinson's disease prior to L-dopa treatment: A case report
title_fullStr Deep brain stimulation for Parkinson's disease prior to L-dopa treatment: A case report
title_full_unstemmed Deep brain stimulation for Parkinson's disease prior to L-dopa treatment: A case report
title_short Deep brain stimulation for Parkinson's disease prior to L-dopa treatment: A case report
title_sort deep brain stimulation for parkinson's disease prior to l-dopa treatment: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134109/
https://www.ncbi.nlm.nih.gov/pubmed/27990314
http://dx.doi.org/10.4103/2152-7806.194064
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