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The impact of deep brain stimulation on tinnitus

BACKGROUND: Tinnitus is a disorder of the nervous system that cannot be adequately treated with current therapies. The effect of neuromodulation induced by deep brain stimulation (DBS) on tinnitus has not been studied well. This study investigated the effect of DBS on tinnitus by use of a multicente...

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Autores principales: Smit, Jasper V., Janssen, Marcus L. F., Engelhard, Malou, de Bie, Rob M. A., Schuurman, P. Richard, Contarino, Maria F., Mosch, Arne, Temel, Yasin, Stokroos, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134112/
https://www.ncbi.nlm.nih.gov/pubmed/27994936
http://dx.doi.org/10.4103/2152-7806.194156
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author Smit, Jasper V.
Janssen, Marcus L. F.
Engelhard, Malou
de Bie, Rob M. A.
Schuurman, P. Richard
Contarino, Maria F.
Mosch, Arne
Temel, Yasin
Stokroos, Robert J.
author_facet Smit, Jasper V.
Janssen, Marcus L. F.
Engelhard, Malou
de Bie, Rob M. A.
Schuurman, P. Richard
Contarino, Maria F.
Mosch, Arne
Temel, Yasin
Stokroos, Robert J.
author_sort Smit, Jasper V.
collection PubMed
description BACKGROUND: Tinnitus is a disorder of the nervous system that cannot be adequately treated with current therapies. The effect of neuromodulation induced by deep brain stimulation (DBS) on tinnitus has not been studied well. This study investigated the effect of DBS on tinnitus by use of a multicenter questionnaire study. METHODS: Tinnitus was retrospectively assessed prior to DBS and at the current situation (with DBS). From the 685 questionnaires, 443 were returned. A control group was one-to-one matched to DBS patients who had tinnitus before DBS (n = 61). Tinnitus was assessed by the tinnitus handicap inventory (THI) and visual analog scales (VAS) of loudness and burden. RESULTS: The THI decreased significantly during DBS compared to the situation prior to surgery (from 18.9 to 15.1, P < .001), which was only significant for DBS in the subthalamic nucleus (STN). The THI in the control group (36.9 to 35.5, P = 0.50) and other DBS targets did not change. The VAS loudness increased in the control group (5.4 to 6.0 P < .01). CONCLUSION: DBS might have a modulatory effect on tinnitus. Our study suggests that DBS of the STN may have a beneficial effect on tinnitus, but most likely other nuclei linked to the tinnitus circuitry might be even more effective.
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spelling pubmed-51341122016-12-19 The impact of deep brain stimulation on tinnitus Smit, Jasper V. Janssen, Marcus L. F. Engelhard, Malou de Bie, Rob M. A. Schuurman, P. Richard Contarino, Maria F. Mosch, Arne Temel, Yasin Stokroos, Robert J. Surg Neurol Int Original Article BACKGROUND: Tinnitus is a disorder of the nervous system that cannot be adequately treated with current therapies. The effect of neuromodulation induced by deep brain stimulation (DBS) on tinnitus has not been studied well. This study investigated the effect of DBS on tinnitus by use of a multicenter questionnaire study. METHODS: Tinnitus was retrospectively assessed prior to DBS and at the current situation (with DBS). From the 685 questionnaires, 443 were returned. A control group was one-to-one matched to DBS patients who had tinnitus before DBS (n = 61). Tinnitus was assessed by the tinnitus handicap inventory (THI) and visual analog scales (VAS) of loudness and burden. RESULTS: The THI decreased significantly during DBS compared to the situation prior to surgery (from 18.9 to 15.1, P < .001), which was only significant for DBS in the subthalamic nucleus (STN). The THI in the control group (36.9 to 35.5, P = 0.50) and other DBS targets did not change. The VAS loudness increased in the control group (5.4 to 6.0 P < .01). CONCLUSION: DBS might have a modulatory effect on tinnitus. Our study suggests that DBS of the STN may have a beneficial effect on tinnitus, but most likely other nuclei linked to the tinnitus circuitry might be even more effective. Medknow Publications & Media Pvt Ltd 2016-11-14 /pmc/articles/PMC5134112/ /pubmed/27994936 http://dx.doi.org/10.4103/2152-7806.194156 Text en Copyright: © 2016 Surgical Neurology International http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Smit, Jasper V.
Janssen, Marcus L. F.
Engelhard, Malou
de Bie, Rob M. A.
Schuurman, P. Richard
Contarino, Maria F.
Mosch, Arne
Temel, Yasin
Stokroos, Robert J.
The impact of deep brain stimulation on tinnitus
title The impact of deep brain stimulation on tinnitus
title_full The impact of deep brain stimulation on tinnitus
title_fullStr The impact of deep brain stimulation on tinnitus
title_full_unstemmed The impact of deep brain stimulation on tinnitus
title_short The impact of deep brain stimulation on tinnitus
title_sort impact of deep brain stimulation on tinnitus
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134112/
https://www.ncbi.nlm.nih.gov/pubmed/27994936
http://dx.doi.org/10.4103/2152-7806.194156
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