Cargando…
All‐trans retinoic acid (ATRA) in non‐promyelocytic acute myeloid leukemia (AML): results of combination of ATRA with low‐dose Ara‐C in three elderly patients with NPM1‐mutated AML unfit for intensive chemotherapy and review of the literature
Based upon the clinical behavior of three patients, we suggest that the combination of low‐dose Ara‐C and all‐trans retinoic acid may potentially be effective in some elderly patients, unfit for intensive chemotherapy, affected with NPM1‐mutated acute myeloid leukemia without FLT3 mutations, warrant...
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2016
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134148/ https://www.ncbi.nlm.nih.gov/pubmed/27980750 http://dx.doi.org/10.1002/ccr3.723 |
| _version_ | 1782471411339624448 |
|---|---|
| author | Forghieri, Fabio Bigliardi, Sara Quadrelli, Chiara Morselli, Monica Potenza, Leonardo Paolini, Ambra Colaci, Elisabetta Barozzi, Patrizia Zucchini, Patrizia Riva, Giovanni Vallerini, Daniela Lagreca, Ivana Marasca, Roberto Narni, Franco Venditti, Adriano Martelli, Maria Paola Falini, Brunangelo Lo Coco, Francesco Amadori, Sergio Luppi, Mario |
| author_facet | Forghieri, Fabio Bigliardi, Sara Quadrelli, Chiara Morselli, Monica Potenza, Leonardo Paolini, Ambra Colaci, Elisabetta Barozzi, Patrizia Zucchini, Patrizia Riva, Giovanni Vallerini, Daniela Lagreca, Ivana Marasca, Roberto Narni, Franco Venditti, Adriano Martelli, Maria Paola Falini, Brunangelo Lo Coco, Francesco Amadori, Sergio Luppi, Mario |
| author_sort | Forghieri, Fabio |
| collection | PubMed |
| description | Based upon the clinical behavior of three patients, we suggest that the combination of low‐dose Ara‐C and all‐trans retinoic acid may potentially be effective in some elderly patients, unfit for intensive chemotherapy, affected with NPM1‐mutated acute myeloid leukemia without FLT3 mutations, warranting perspective clinical studies in these selected patients. |
| format | Online Article Text |
| id | pubmed-5134148 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-51341482016-12-15 All‐trans retinoic acid (ATRA) in non‐promyelocytic acute myeloid leukemia (AML): results of combination of ATRA with low‐dose Ara‐C in three elderly patients with NPM1‐mutated AML unfit for intensive chemotherapy and review of the literature Forghieri, Fabio Bigliardi, Sara Quadrelli, Chiara Morselli, Monica Potenza, Leonardo Paolini, Ambra Colaci, Elisabetta Barozzi, Patrizia Zucchini, Patrizia Riva, Giovanni Vallerini, Daniela Lagreca, Ivana Marasca, Roberto Narni, Franco Venditti, Adriano Martelli, Maria Paola Falini, Brunangelo Lo Coco, Francesco Amadori, Sergio Luppi, Mario Clin Case Rep Case Reports Based upon the clinical behavior of three patients, we suggest that the combination of low‐dose Ara‐C and all‐trans retinoic acid may potentially be effective in some elderly patients, unfit for intensive chemotherapy, affected with NPM1‐mutated acute myeloid leukemia without FLT3 mutations, warranting perspective clinical studies in these selected patients. John Wiley and Sons Inc. 2016-10-24 /pmc/articles/PMC5134148/ /pubmed/27980750 http://dx.doi.org/10.1002/ccr3.723 Text en © 2016 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| spellingShingle | Case Reports Forghieri, Fabio Bigliardi, Sara Quadrelli, Chiara Morselli, Monica Potenza, Leonardo Paolini, Ambra Colaci, Elisabetta Barozzi, Patrizia Zucchini, Patrizia Riva, Giovanni Vallerini, Daniela Lagreca, Ivana Marasca, Roberto Narni, Franco Venditti, Adriano Martelli, Maria Paola Falini, Brunangelo Lo Coco, Francesco Amadori, Sergio Luppi, Mario All‐trans retinoic acid (ATRA) in non‐promyelocytic acute myeloid leukemia (AML): results of combination of ATRA with low‐dose Ara‐C in three elderly patients with NPM1‐mutated AML unfit for intensive chemotherapy and review of the literature |
| title | All‐trans retinoic acid (ATRA) in non‐promyelocytic acute myeloid leukemia (AML): results of combination of ATRA with low‐dose Ara‐C in three elderly patients with NPM1‐mutated AML unfit for intensive chemotherapy and review of the literature |
| title_full | All‐trans retinoic acid (ATRA) in non‐promyelocytic acute myeloid leukemia (AML): results of combination of ATRA with low‐dose Ara‐C in three elderly patients with NPM1‐mutated AML unfit for intensive chemotherapy and review of the literature |
| title_fullStr | All‐trans retinoic acid (ATRA) in non‐promyelocytic acute myeloid leukemia (AML): results of combination of ATRA with low‐dose Ara‐C in three elderly patients with NPM1‐mutated AML unfit for intensive chemotherapy and review of the literature |
| title_full_unstemmed | All‐trans retinoic acid (ATRA) in non‐promyelocytic acute myeloid leukemia (AML): results of combination of ATRA with low‐dose Ara‐C in three elderly patients with NPM1‐mutated AML unfit for intensive chemotherapy and review of the literature |
| title_short | All‐trans retinoic acid (ATRA) in non‐promyelocytic acute myeloid leukemia (AML): results of combination of ATRA with low‐dose Ara‐C in three elderly patients with NPM1‐mutated AML unfit for intensive chemotherapy and review of the literature |
| title_sort | all‐trans retinoic acid (atra) in non‐promyelocytic acute myeloid leukemia (aml): results of combination of atra with low‐dose ara‐c in three elderly patients with npm1‐mutated aml unfit for intensive chemotherapy and review of the literature |
| topic | Case Reports |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134148/ https://www.ncbi.nlm.nih.gov/pubmed/27980750 http://dx.doi.org/10.1002/ccr3.723 |
| work_keys_str_mv | AT forghierifabio alltransretinoicacidatrainnonpromyelocyticacutemyeloidleukemiaamlresultsofcombinationofatrawithlowdosearacinthreeelderlypatientswithnpm1mutatedamlunfitforintensivechemotherapyandreviewoftheliterature AT bigliardisara alltransretinoicacidatrainnonpromyelocyticacutemyeloidleukemiaamlresultsofcombinationofatrawithlowdosearacinthreeelderlypatientswithnpm1mutatedamlunfitforintensivechemotherapyandreviewoftheliterature AT quadrellichiara alltransretinoicacidatrainnonpromyelocyticacutemyeloidleukemiaamlresultsofcombinationofatrawithlowdosearacinthreeelderlypatientswithnpm1mutatedamlunfitforintensivechemotherapyandreviewoftheliterature AT morsellimonica alltransretinoicacidatrainnonpromyelocyticacutemyeloidleukemiaamlresultsofcombinationofatrawithlowdosearacinthreeelderlypatientswithnpm1mutatedamlunfitforintensivechemotherapyandreviewoftheliterature AT potenzaleonardo alltransretinoicacidatrainnonpromyelocyticacutemyeloidleukemiaamlresultsofcombinationofatrawithlowdosearacinthreeelderlypatientswithnpm1mutatedamlunfitforintensivechemotherapyandreviewoftheliterature AT paoliniambra alltransretinoicacidatrainnonpromyelocyticacutemyeloidleukemiaamlresultsofcombinationofatrawithlowdosearacinthreeelderlypatientswithnpm1mutatedamlunfitforintensivechemotherapyandreviewoftheliterature AT colacielisabetta alltransretinoicacidatrainnonpromyelocyticacutemyeloidleukemiaamlresultsofcombinationofatrawithlowdosearacinthreeelderlypatientswithnpm1mutatedamlunfitforintensivechemotherapyandreviewoftheliterature AT barozzipatrizia alltransretinoicacidatrainnonpromyelocyticacutemyeloidleukemiaamlresultsofcombinationofatrawithlowdosearacinthreeelderlypatientswithnpm1mutatedamlunfitforintensivechemotherapyandreviewoftheliterature AT zucchinipatrizia alltransretinoicacidatrainnonpromyelocyticacutemyeloidleukemiaamlresultsofcombinationofatrawithlowdosearacinthreeelderlypatientswithnpm1mutatedamlunfitforintensivechemotherapyandreviewoftheliterature AT rivagiovanni alltransretinoicacidatrainnonpromyelocyticacutemyeloidleukemiaamlresultsofcombinationofatrawithlowdosearacinthreeelderlypatientswithnpm1mutatedamlunfitforintensivechemotherapyandreviewoftheliterature AT vallerinidaniela alltransretinoicacidatrainnonpromyelocyticacutemyeloidleukemiaamlresultsofcombinationofatrawithlowdosearacinthreeelderlypatientswithnpm1mutatedamlunfitforintensivechemotherapyandreviewoftheliterature AT lagrecaivana alltransretinoicacidatrainnonpromyelocyticacutemyeloidleukemiaamlresultsofcombinationofatrawithlowdosearacinthreeelderlypatientswithnpm1mutatedamlunfitforintensivechemotherapyandreviewoftheliterature AT marascaroberto alltransretinoicacidatrainnonpromyelocyticacutemyeloidleukemiaamlresultsofcombinationofatrawithlowdosearacinthreeelderlypatientswithnpm1mutatedamlunfitforintensivechemotherapyandreviewoftheliterature AT narnifranco alltransretinoicacidatrainnonpromyelocyticacutemyeloidleukemiaamlresultsofcombinationofatrawithlowdosearacinthreeelderlypatientswithnpm1mutatedamlunfitforintensivechemotherapyandreviewoftheliterature AT vendittiadriano alltransretinoicacidatrainnonpromyelocyticacutemyeloidleukemiaamlresultsofcombinationofatrawithlowdosearacinthreeelderlypatientswithnpm1mutatedamlunfitforintensivechemotherapyandreviewoftheliterature AT martellimariapaola alltransretinoicacidatrainnonpromyelocyticacutemyeloidleukemiaamlresultsofcombinationofatrawithlowdosearacinthreeelderlypatientswithnpm1mutatedamlunfitforintensivechemotherapyandreviewoftheliterature AT falinibrunangelo alltransretinoicacidatrainnonpromyelocyticacutemyeloidleukemiaamlresultsofcombinationofatrawithlowdosearacinthreeelderlypatientswithnpm1mutatedamlunfitforintensivechemotherapyandreviewoftheliterature AT lococofrancesco alltransretinoicacidatrainnonpromyelocyticacutemyeloidleukemiaamlresultsofcombinationofatrawithlowdosearacinthreeelderlypatientswithnpm1mutatedamlunfitforintensivechemotherapyandreviewoftheliterature AT amadorisergio alltransretinoicacidatrainnonpromyelocyticacutemyeloidleukemiaamlresultsofcombinationofatrawithlowdosearacinthreeelderlypatientswithnpm1mutatedamlunfitforintensivechemotherapyandreviewoftheliterature AT luppimario alltransretinoicacidatrainnonpromyelocyticacutemyeloidleukemiaamlresultsofcombinationofatrawithlowdosearacinthreeelderlypatientswithnpm1mutatedamlunfitforintensivechemotherapyandreviewoftheliterature |