Potential of Small Molecule–Mediated Reprogramming of Rod Photoreceptors to Treat Retinitis Pigmentosa

PURPOSE: Mutations in rod photoreceptor genes can cause retinitis pigmentosa (RP). Rod gene expression is regulated by the nuclear hormone receptor, Nr2e3. Genetic deletion of Nr2e3 reprograms rods into cells that resemble cone photoreceptors, and might therefore prevent their death from some forms...

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Detalles Bibliográficos
Autores principales: Nakamura, Paul A., Tang, Shibing, Shimchuk, Andy A., Ding, Sheng, Reh, Thomas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2016
Materias:
Retinal Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134355/
https://www.ncbi.nlm.nih.gov/pubmed/27893103
http://dx.doi.org/10.1167/iovs.16-20177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134355/
https://www.ncbi.nlm.nih.gov/pubmed/27893103
http://dx.doi.org/10.1167/iovs.16-20177

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