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Body Mass Index Can Increase the Risk of Gallbladder Cancer: A Meta-Analysis of 14 Cohort Studies

BACKGROUND: This study sought to appraise the association between raised body mass index (BMI) and the risk of gallbladder cancer (GBC) by performing a meta-analysis of 14 cohort studies. MATERIALS/METHODS: Eligible cohort studies were selected by searching PubMed and EMBASE from their inception to...

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Autores principales: Liu, Hao, Zhang, Yong, Ai, Min, Wang, Jun, Jin, Bo, Teng, Zhaowei, Wang, Yansheng, Li, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134363/
https://www.ncbi.nlm.nih.gov/pubmed/27899789
http://dx.doi.org/10.12659/MSMBR.901651
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author Liu, Hao
Zhang, Yong
Ai, Min
Wang, Jun
Jin, Bo
Teng, Zhaowei
Wang, Yansheng
Li, Li
author_facet Liu, Hao
Zhang, Yong
Ai, Min
Wang, Jun
Jin, Bo
Teng, Zhaowei
Wang, Yansheng
Li, Li
author_sort Liu, Hao
collection PubMed
description BACKGROUND: This study sought to appraise the association between raised body mass index (BMI) and the risk of gallbladder cancer (GBC) by performing a meta-analysis of 14 cohort studies. MATERIALS/METHODS: Eligible cohort studies were selected by searching PubMed and EMBASE from their inception to May 26, 2016, and the reference lists of retrieved articles were also consulted. The information was screened by two authors separately. We used a fixed-effects model to calculate the overall pooled risk estimates. A random-effects model was used to identify heterogeneity. RESULTS: The meta-analysis incorporated 14 cohort studies. Nine papers were deemed to be of high quality based on the Newcastle-Ottawa Scale (NOS). Compared with normal weight (BMI 18.5–24.9 kg/m(2)), the overall pooled relative risks (RR) of GBC was 1.45 (95% CI 1.30–1.61) for excess body weight individuals (BMI ≥25 kg/m(2)); 1.10 (95% CI 1.02–1.18) for overweight persons (BMI 25–29.9 kg/m(2)) and 1.69(95% CI 1.54–1.86) for obese folks (BMI ≥30 kg/m(2)). A higher risk of GBC was presented in obese women (women: RR 1.78, 95% CI 1.59–1.99; men: RR 1.50, 95% CI 1.25–1.79). And a positive relationship between overweight and GBC risk was also displayed in female (RR 1.25, 95% CI 1.11–1.40), but not in male (RR 1.01, 95% CI 0.93–1.11). The sensitivity analysis indicated stable results, and no publication bias was observed. CONCLUSIONS: This meta-analysis of 14 cohort studies demonstrated that raised BMI has a dramatic association with risk of GBC, especially in women. But, no association between overweight and GBC in men was found.
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spelling pubmed-51343632016-12-07 Body Mass Index Can Increase the Risk of Gallbladder Cancer: A Meta-Analysis of 14 Cohort Studies Liu, Hao Zhang, Yong Ai, Min Wang, Jun Jin, Bo Teng, Zhaowei Wang, Yansheng Li, Li Med Sci Monit Basic Res Meta-Analysis BACKGROUND: This study sought to appraise the association between raised body mass index (BMI) and the risk of gallbladder cancer (GBC) by performing a meta-analysis of 14 cohort studies. MATERIALS/METHODS: Eligible cohort studies were selected by searching PubMed and EMBASE from their inception to May 26, 2016, and the reference lists of retrieved articles were also consulted. The information was screened by two authors separately. We used a fixed-effects model to calculate the overall pooled risk estimates. A random-effects model was used to identify heterogeneity. RESULTS: The meta-analysis incorporated 14 cohort studies. Nine papers were deemed to be of high quality based on the Newcastle-Ottawa Scale (NOS). Compared with normal weight (BMI 18.5–24.9 kg/m(2)), the overall pooled relative risks (RR) of GBC was 1.45 (95% CI 1.30–1.61) for excess body weight individuals (BMI ≥25 kg/m(2)); 1.10 (95% CI 1.02–1.18) for overweight persons (BMI 25–29.9 kg/m(2)) and 1.69(95% CI 1.54–1.86) for obese folks (BMI ≥30 kg/m(2)). A higher risk of GBC was presented in obese women (women: RR 1.78, 95% CI 1.59–1.99; men: RR 1.50, 95% CI 1.25–1.79). And a positive relationship between overweight and GBC risk was also displayed in female (RR 1.25, 95% CI 1.11–1.40), but not in male (RR 1.01, 95% CI 0.93–1.11). The sensitivity analysis indicated stable results, and no publication bias was observed. CONCLUSIONS: This meta-analysis of 14 cohort studies demonstrated that raised BMI has a dramatic association with risk of GBC, especially in women. But, no association between overweight and GBC in men was found. International Scientific Literature, Inc. 2016-11-30 /pmc/articles/PMC5134363/ /pubmed/27899789 http://dx.doi.org/10.12659/MSMBR.901651 Text en © Med Sci Monit, 2016 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
spellingShingle Meta-Analysis
Liu, Hao
Zhang, Yong
Ai, Min
Wang, Jun
Jin, Bo
Teng, Zhaowei
Wang, Yansheng
Li, Li
Body Mass Index Can Increase the Risk of Gallbladder Cancer: A Meta-Analysis of 14 Cohort Studies
title Body Mass Index Can Increase the Risk of Gallbladder Cancer: A Meta-Analysis of 14 Cohort Studies
title_full Body Mass Index Can Increase the Risk of Gallbladder Cancer: A Meta-Analysis of 14 Cohort Studies
title_fullStr Body Mass Index Can Increase the Risk of Gallbladder Cancer: A Meta-Analysis of 14 Cohort Studies
title_full_unstemmed Body Mass Index Can Increase the Risk of Gallbladder Cancer: A Meta-Analysis of 14 Cohort Studies
title_short Body Mass Index Can Increase the Risk of Gallbladder Cancer: A Meta-Analysis of 14 Cohort Studies
title_sort body mass index can increase the risk of gallbladder cancer: a meta-analysis of 14 cohort studies
topic Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134363/
https://www.ncbi.nlm.nih.gov/pubmed/27899789
http://dx.doi.org/10.12659/MSMBR.901651
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