Cargando…
Body Mass Index Can Increase the Risk of Gallbladder Cancer: A Meta-Analysis of 14 Cohort Studies
BACKGROUND: This study sought to appraise the association between raised body mass index (BMI) and the risk of gallbladder cancer (GBC) by performing a meta-analysis of 14 cohort studies. MATERIALS/METHODS: Eligible cohort studies were selected by searching PubMed and EMBASE from their inception to...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134363/ https://www.ncbi.nlm.nih.gov/pubmed/27899789 http://dx.doi.org/10.12659/MSMBR.901651 |
_version_ | 1782471443442827264 |
---|---|
author | Liu, Hao Zhang, Yong Ai, Min Wang, Jun Jin, Bo Teng, Zhaowei Wang, Yansheng Li, Li |
author_facet | Liu, Hao Zhang, Yong Ai, Min Wang, Jun Jin, Bo Teng, Zhaowei Wang, Yansheng Li, Li |
author_sort | Liu, Hao |
collection | PubMed |
description | BACKGROUND: This study sought to appraise the association between raised body mass index (BMI) and the risk of gallbladder cancer (GBC) by performing a meta-analysis of 14 cohort studies. MATERIALS/METHODS: Eligible cohort studies were selected by searching PubMed and EMBASE from their inception to May 26, 2016, and the reference lists of retrieved articles were also consulted. The information was screened by two authors separately. We used a fixed-effects model to calculate the overall pooled risk estimates. A random-effects model was used to identify heterogeneity. RESULTS: The meta-analysis incorporated 14 cohort studies. Nine papers were deemed to be of high quality based on the Newcastle-Ottawa Scale (NOS). Compared with normal weight (BMI 18.5–24.9 kg/m(2)), the overall pooled relative risks (RR) of GBC was 1.45 (95% CI 1.30–1.61) for excess body weight individuals (BMI ≥25 kg/m(2)); 1.10 (95% CI 1.02–1.18) for overweight persons (BMI 25–29.9 kg/m(2)) and 1.69(95% CI 1.54–1.86) for obese folks (BMI ≥30 kg/m(2)). A higher risk of GBC was presented in obese women (women: RR 1.78, 95% CI 1.59–1.99; men: RR 1.50, 95% CI 1.25–1.79). And a positive relationship between overweight and GBC risk was also displayed in female (RR 1.25, 95% CI 1.11–1.40), but not in male (RR 1.01, 95% CI 0.93–1.11). The sensitivity analysis indicated stable results, and no publication bias was observed. CONCLUSIONS: This meta-analysis of 14 cohort studies demonstrated that raised BMI has a dramatic association with risk of GBC, especially in women. But, no association between overweight and GBC in men was found. |
format | Online Article Text |
id | pubmed-5134363 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-51343632016-12-07 Body Mass Index Can Increase the Risk of Gallbladder Cancer: A Meta-Analysis of 14 Cohort Studies Liu, Hao Zhang, Yong Ai, Min Wang, Jun Jin, Bo Teng, Zhaowei Wang, Yansheng Li, Li Med Sci Monit Basic Res Meta-Analysis BACKGROUND: This study sought to appraise the association between raised body mass index (BMI) and the risk of gallbladder cancer (GBC) by performing a meta-analysis of 14 cohort studies. MATERIALS/METHODS: Eligible cohort studies were selected by searching PubMed and EMBASE from their inception to May 26, 2016, and the reference lists of retrieved articles were also consulted. The information was screened by two authors separately. We used a fixed-effects model to calculate the overall pooled risk estimates. A random-effects model was used to identify heterogeneity. RESULTS: The meta-analysis incorporated 14 cohort studies. Nine papers were deemed to be of high quality based on the Newcastle-Ottawa Scale (NOS). Compared with normal weight (BMI 18.5–24.9 kg/m(2)), the overall pooled relative risks (RR) of GBC was 1.45 (95% CI 1.30–1.61) for excess body weight individuals (BMI ≥25 kg/m(2)); 1.10 (95% CI 1.02–1.18) for overweight persons (BMI 25–29.9 kg/m(2)) and 1.69(95% CI 1.54–1.86) for obese folks (BMI ≥30 kg/m(2)). A higher risk of GBC was presented in obese women (women: RR 1.78, 95% CI 1.59–1.99; men: RR 1.50, 95% CI 1.25–1.79). And a positive relationship between overweight and GBC risk was also displayed in female (RR 1.25, 95% CI 1.11–1.40), but not in male (RR 1.01, 95% CI 0.93–1.11). The sensitivity analysis indicated stable results, and no publication bias was observed. CONCLUSIONS: This meta-analysis of 14 cohort studies demonstrated that raised BMI has a dramatic association with risk of GBC, especially in women. But, no association between overweight and GBC in men was found. International Scientific Literature, Inc. 2016-11-30 /pmc/articles/PMC5134363/ /pubmed/27899789 http://dx.doi.org/10.12659/MSMBR.901651 Text en © Med Sci Monit, 2016 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) |
spellingShingle | Meta-Analysis Liu, Hao Zhang, Yong Ai, Min Wang, Jun Jin, Bo Teng, Zhaowei Wang, Yansheng Li, Li Body Mass Index Can Increase the Risk of Gallbladder Cancer: A Meta-Analysis of 14 Cohort Studies |
title | Body Mass Index Can Increase the Risk of Gallbladder Cancer: A Meta-Analysis of 14 Cohort Studies |
title_full | Body Mass Index Can Increase the Risk of Gallbladder Cancer: A Meta-Analysis of 14 Cohort Studies |
title_fullStr | Body Mass Index Can Increase the Risk of Gallbladder Cancer: A Meta-Analysis of 14 Cohort Studies |
title_full_unstemmed | Body Mass Index Can Increase the Risk of Gallbladder Cancer: A Meta-Analysis of 14 Cohort Studies |
title_short | Body Mass Index Can Increase the Risk of Gallbladder Cancer: A Meta-Analysis of 14 Cohort Studies |
title_sort | body mass index can increase the risk of gallbladder cancer: a meta-analysis of 14 cohort studies |
topic | Meta-Analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134363/ https://www.ncbi.nlm.nih.gov/pubmed/27899789 http://dx.doi.org/10.12659/MSMBR.901651 |
work_keys_str_mv | AT liuhao bodymassindexcanincreasetheriskofgallbladdercancerametaanalysisof14cohortstudies AT zhangyong bodymassindexcanincreasetheriskofgallbladdercancerametaanalysisof14cohortstudies AT aimin bodymassindexcanincreasetheriskofgallbladdercancerametaanalysisof14cohortstudies AT wangjun bodymassindexcanincreasetheriskofgallbladdercancerametaanalysisof14cohortstudies AT jinbo bodymassindexcanincreasetheriskofgallbladdercancerametaanalysisof14cohortstudies AT tengzhaowei bodymassindexcanincreasetheriskofgallbladdercancerametaanalysisof14cohortstudies AT wangyansheng bodymassindexcanincreasetheriskofgallbladdercancerametaanalysisof14cohortstudies AT lili bodymassindexcanincreasetheriskofgallbladdercancerametaanalysisof14cohortstudies |