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A Robust, Enzyme-Free Glucose Sensor Based on Lysine-Assisted CuO Nanostructures

The production of a nanomaterial with enhanced and desirable electrocatalytic properties is of prime importance, and the commercialization of devices containing these materials is a challenging task. In this study, unique cupric oxide (CuO) nanostructures were synthesized using lysine as a soft temp...

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Autores principales: Baloach, Qurrat-ul-Ain, Tahira, Aneela, Mallah, Arfana Begum, Abro, Muhammad Ishaq, Uddin, Siraj, Willander, Magnus, Ibupoto, Zafar Hussain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134537/
https://www.ncbi.nlm.nih.gov/pubmed/27854253
http://dx.doi.org/10.3390/s16111878
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author Baloach, Qurrat-ul-Ain
Tahira, Aneela
Mallah, Arfana Begum
Abro, Muhammad Ishaq
Uddin, Siraj
Willander, Magnus
Ibupoto, Zafar Hussain
author_facet Baloach, Qurrat-ul-Ain
Tahira, Aneela
Mallah, Arfana Begum
Abro, Muhammad Ishaq
Uddin, Siraj
Willander, Magnus
Ibupoto, Zafar Hussain
author_sort Baloach, Qurrat-ul-Ain
collection PubMed
description The production of a nanomaterial with enhanced and desirable electrocatalytic properties is of prime importance, and the commercialization of devices containing these materials is a challenging task. In this study, unique cupric oxide (CuO) nanostructures were synthesized using lysine as a soft template for the evolution of morphology via a rapid and boiled hydrothermal method. The morphology and structure of the synthesized CuO nanomaterial were characterized using scanning electron microscopy (SEM) and X-ray diffraction (XRD), respectively. The prepared CuO nanostructures showed high potential for use in the electrocatalytic oxidation of glucose in an alkaline medium. The proposed enzyme-free glucose sensor demonstrated a robust response to glucose with a wide linear range and high sensitivity, selectivity, stability, and reproducibility. To explore its practical feasibility, the glucose content of serum samples was successfully determined using the enzyme-free sensor. An analytical recovery method was used to measure the actual glucose from the serum samples, and the results were satisfactory. Moreover, the presented glucose sensor has high chemical stability and can be reused for repetitive measurements. This study introduces an enzyme-free glucose sensor as an alternative tool for clinical glucose quantification.
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spelling pubmed-51345372017-01-03 A Robust, Enzyme-Free Glucose Sensor Based on Lysine-Assisted CuO Nanostructures Baloach, Qurrat-ul-Ain Tahira, Aneela Mallah, Arfana Begum Abro, Muhammad Ishaq Uddin, Siraj Willander, Magnus Ibupoto, Zafar Hussain Sensors (Basel) Article The production of a nanomaterial with enhanced and desirable electrocatalytic properties is of prime importance, and the commercialization of devices containing these materials is a challenging task. In this study, unique cupric oxide (CuO) nanostructures were synthesized using lysine as a soft template for the evolution of morphology via a rapid and boiled hydrothermal method. The morphology and structure of the synthesized CuO nanomaterial were characterized using scanning electron microscopy (SEM) and X-ray diffraction (XRD), respectively. The prepared CuO nanostructures showed high potential for use in the electrocatalytic oxidation of glucose in an alkaline medium. The proposed enzyme-free glucose sensor demonstrated a robust response to glucose with a wide linear range and high sensitivity, selectivity, stability, and reproducibility. To explore its practical feasibility, the glucose content of serum samples was successfully determined using the enzyme-free sensor. An analytical recovery method was used to measure the actual glucose from the serum samples, and the results were satisfactory. Moreover, the presented glucose sensor has high chemical stability and can be reused for repetitive measurements. This study introduces an enzyme-free glucose sensor as an alternative tool for clinical glucose quantification. MDPI 2016-11-14 /pmc/articles/PMC5134537/ /pubmed/27854253 http://dx.doi.org/10.3390/s16111878 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Baloach, Qurrat-ul-Ain
Tahira, Aneela
Mallah, Arfana Begum
Abro, Muhammad Ishaq
Uddin, Siraj
Willander, Magnus
Ibupoto, Zafar Hussain
A Robust, Enzyme-Free Glucose Sensor Based on Lysine-Assisted CuO Nanostructures
title A Robust, Enzyme-Free Glucose Sensor Based on Lysine-Assisted CuO Nanostructures
title_full A Robust, Enzyme-Free Glucose Sensor Based on Lysine-Assisted CuO Nanostructures
title_fullStr A Robust, Enzyme-Free Glucose Sensor Based on Lysine-Assisted CuO Nanostructures
title_full_unstemmed A Robust, Enzyme-Free Glucose Sensor Based on Lysine-Assisted CuO Nanostructures
title_short A Robust, Enzyme-Free Glucose Sensor Based on Lysine-Assisted CuO Nanostructures
title_sort robust, enzyme-free glucose sensor based on lysine-assisted cuo nanostructures
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134537/
https://www.ncbi.nlm.nih.gov/pubmed/27854253
http://dx.doi.org/10.3390/s16111878
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