Hydroxyurea-Mediated Cytotoxicity Without Inhibition of Ribonucleotide Reductase

In many organisms, hydroxyurea (HU) inhibits class I ribonucleotide reductase, leading to lowered cellular pools of deoxyribonucleoside triphosphates. The reduced levels for DNA precursors is believed to cause replication fork stalling. Upon treatment of the hyperthermophilic archaeon Sulfolobus sol...

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Detalles Bibliográficos
Autores principales: Liew, Li Phing, Lim, Zun Yi, Cohen, Matan, Kong, Ziqing, Marjavaara, Lisette, Chabes, Andrei, Bell, Stephen D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134839/
https://www.ncbi.nlm.nih.gov/pubmed/27806303
http://dx.doi.org/10.1016/j.celrep.2016.10.024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134839/
https://www.ncbi.nlm.nih.gov/pubmed/27806303
http://dx.doi.org/10.1016/j.celrep.2016.10.024

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