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Structural insights into functional amyloid inhibition in Gram −ve bacteria

Amyloids are proteinaceous aggregates known for their role in debilitating degenerative diseases involving protein dysfunction. Many forms of functional amyloid are also produced in nature and often these systems require careful control of their assembly to avoid the potentially toxic effects. The b...

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Detalles Bibliográficos
Autores principales: Hawthorne, William, Rouse, Sarah, Sewell, Lee, Matthews, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135000/
https://www.ncbi.nlm.nih.gov/pubmed/27913673
http://dx.doi.org/10.1042/BST20160245
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author Hawthorne, William
Rouse, Sarah
Sewell, Lee
Matthews, Stephen J.
author_facet Hawthorne, William
Rouse, Sarah
Sewell, Lee
Matthews, Stephen J.
author_sort Hawthorne, William
collection PubMed
description Amyloids are proteinaceous aggregates known for their role in debilitating degenerative diseases involving protein dysfunction. Many forms of functional amyloid are also produced in nature and often these systems require careful control of their assembly to avoid the potentially toxic effects. The best-characterised functional amyloid system is the bacterial curli system. Three natural inhibitors of bacterial curli amyloid have been identified and recently characterised structurally. Here, we compare common structural features of CsgC, CsgE and CsgH and discuss the potential implications for general inhibition of amyloid.
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spelling pubmed-51350002016-12-16 Structural insights into functional amyloid inhibition in Gram −ve bacteria Hawthorne, William Rouse, Sarah Sewell, Lee Matthews, Stephen J. Biochem Soc Trans Structural Aspects of Infectious Disease Amyloids are proteinaceous aggregates known for their role in debilitating degenerative diseases involving protein dysfunction. Many forms of functional amyloid are also produced in nature and often these systems require careful control of their assembly to avoid the potentially toxic effects. The best-characterised functional amyloid system is the bacterial curli system. Three natural inhibitors of bacterial curli amyloid have been identified and recently characterised structurally. Here, we compare common structural features of CsgC, CsgE and CsgH and discuss the potential implications for general inhibition of amyloid. Portland Press Ltd. 2016-12-15 2016-12-02 /pmc/articles/PMC5135000/ /pubmed/27913673 http://dx.doi.org/10.1042/BST20160245 Text en © 2016 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0) .
spellingShingle Structural Aspects of Infectious Disease
Hawthorne, William
Rouse, Sarah
Sewell, Lee
Matthews, Stephen J.
Structural insights into functional amyloid inhibition in Gram −ve bacteria
title Structural insights into functional amyloid inhibition in Gram −ve bacteria
title_full Structural insights into functional amyloid inhibition in Gram −ve bacteria
title_fullStr Structural insights into functional amyloid inhibition in Gram −ve bacteria
title_full_unstemmed Structural insights into functional amyloid inhibition in Gram −ve bacteria
title_short Structural insights into functional amyloid inhibition in Gram −ve bacteria
title_sort structural insights into functional amyloid inhibition in gram −ve bacteria
topic Structural Aspects of Infectious Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135000/
https://www.ncbi.nlm.nih.gov/pubmed/27913673
http://dx.doi.org/10.1042/BST20160245
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