Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment

In vertebrate neurons, the axon initial segment (AIS) is specialized for action potential initiation. It is organized by a giant 480 Kd variant of ankyrin G (AnkG) that serves as an anchor for ion channels and is required for a plasma membrane diffusion barrier that excludes somatodendritic proteins...

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Detalles Bibliográficos
Autores principales: Jegla, Timothy, Nguyen, Michelle M., Feng, Chengye, Goetschius, Daniel J., Luna, Esteban, van Rossum, Damian B., Kamel, Bishoy, Pisupati, Aditya, Milner, Elliott S., Rolls, Melissa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135030/
https://www.ncbi.nlm.nih.gov/pubmed/27911898
http://dx.doi.org/10.1371/journal.pgen.1006457

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