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Marathon Race Affects Neutrophil Surface Molecules: Role of Inflammatory Mediators
The fatigue induced by marathon races was observed in terms of inflammatory and immunological outcomes. Neutrophil survival and activation are essential for inflammation resolution and contributes directly to the pathogenesis of many infectious and inflammatory conditions. The aim of this study was...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135050/ https://www.ncbi.nlm.nih.gov/pubmed/27911915 http://dx.doi.org/10.1371/journal.pone.0166687 |
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author | Santos, Vinicius Coneglian Sierra, Ana Paula Renno Oliveira, Rodrigo Caçula, Kim Guimarães Momesso, César Miguel Sato, Fabio Takeo Silva, Maysa Braga Barros Oliveira, Heloisa Helena Passos, Maria Elizabeth Pereira de Souza, Diego Ribeiro Gondim, Olivia Santos Benetti, Marino Levada-Pires, Adriana Cristina Ghorayeb, Nabil Kiss, Maria Augusta Peduti Dal Molin Gorjão, Renata Pithon-Curi, Tânia Cristina Cury-Boaventura, Maria Fernanda |
author_facet | Santos, Vinicius Coneglian Sierra, Ana Paula Renno Oliveira, Rodrigo Caçula, Kim Guimarães Momesso, César Miguel Sato, Fabio Takeo Silva, Maysa Braga Barros Oliveira, Heloisa Helena Passos, Maria Elizabeth Pereira de Souza, Diego Ribeiro Gondim, Olivia Santos Benetti, Marino Levada-Pires, Adriana Cristina Ghorayeb, Nabil Kiss, Maria Augusta Peduti Dal Molin Gorjão, Renata Pithon-Curi, Tânia Cristina Cury-Boaventura, Maria Fernanda |
author_sort | Santos, Vinicius Coneglian |
collection | PubMed |
description | The fatigue induced by marathon races was observed in terms of inflammatory and immunological outcomes. Neutrophil survival and activation are essential for inflammation resolution and contributes directly to the pathogenesis of many infectious and inflammatory conditions. The aim of this study was to investigate the effect of marathon races on surface molecules related to neutrophil adhesion and extrinsic apoptosis pathway and its association with inflammatory markers. We evaluated 23 trained male runners at the São Paulo International Marathon 2013. The following components were measured: hematological and inflammatory mediators, muscle damage markers, and neutrophil function. The marathon race induced an increased leukocyte and neutrophil counts; creatine kinase (CK), lactate dehydrogenase (LDH), CK-MB, interleukin (IL)-6, IL-10, and IL-8 levels. C-reactive protein (CRP), IL-12, and tumor necrosis factor (TNF)-α plasma concentrations were significantly higher 24 h and 72 h after the marathon race. Hemoglobin and hematocrit levels decreased 72 h after the marathon race. We also observed an increased intercellular adhesion molecule-1 (ICAM-1) expression and decreasedTNF receptor-1 (TNFR1) expression immediately after and 24 h after the marathon race. We observed an increased DNA fragmentation and L-selectin and Fas receptor expressions in the recovery period, indicating a possible slow rolling phase and delayed neutrophil activation and apoptosis. Marathon racing affects neutrophils adhesion and survival in the course of inflammation, supporting the “open-window” post-exercise hypothesis. |
format | Online Article Text |
id | pubmed-5135050 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-51350502016-12-21 Marathon Race Affects Neutrophil Surface Molecules: Role of Inflammatory Mediators Santos, Vinicius Coneglian Sierra, Ana Paula Renno Oliveira, Rodrigo Caçula, Kim Guimarães Momesso, César Miguel Sato, Fabio Takeo Silva, Maysa Braga Barros Oliveira, Heloisa Helena Passos, Maria Elizabeth Pereira de Souza, Diego Ribeiro Gondim, Olivia Santos Benetti, Marino Levada-Pires, Adriana Cristina Ghorayeb, Nabil Kiss, Maria Augusta Peduti Dal Molin Gorjão, Renata Pithon-Curi, Tânia Cristina Cury-Boaventura, Maria Fernanda PLoS One Research Article The fatigue induced by marathon races was observed in terms of inflammatory and immunological outcomes. Neutrophil survival and activation are essential for inflammation resolution and contributes directly to the pathogenesis of many infectious and inflammatory conditions. The aim of this study was to investigate the effect of marathon races on surface molecules related to neutrophil adhesion and extrinsic apoptosis pathway and its association with inflammatory markers. We evaluated 23 trained male runners at the São Paulo International Marathon 2013. The following components were measured: hematological and inflammatory mediators, muscle damage markers, and neutrophil function. The marathon race induced an increased leukocyte and neutrophil counts; creatine kinase (CK), lactate dehydrogenase (LDH), CK-MB, interleukin (IL)-6, IL-10, and IL-8 levels. C-reactive protein (CRP), IL-12, and tumor necrosis factor (TNF)-α plasma concentrations were significantly higher 24 h and 72 h after the marathon race. Hemoglobin and hematocrit levels decreased 72 h after the marathon race. We also observed an increased intercellular adhesion molecule-1 (ICAM-1) expression and decreasedTNF receptor-1 (TNFR1) expression immediately after and 24 h after the marathon race. We observed an increased DNA fragmentation and L-selectin and Fas receptor expressions in the recovery period, indicating a possible slow rolling phase and delayed neutrophil activation and apoptosis. Marathon racing affects neutrophils adhesion and survival in the course of inflammation, supporting the “open-window” post-exercise hypothesis. Public Library of Science 2016-12-02 /pmc/articles/PMC5135050/ /pubmed/27911915 http://dx.doi.org/10.1371/journal.pone.0166687 Text en © 2016 Santos et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Santos, Vinicius Coneglian Sierra, Ana Paula Renno Oliveira, Rodrigo Caçula, Kim Guimarães Momesso, César Miguel Sato, Fabio Takeo Silva, Maysa Braga Barros Oliveira, Heloisa Helena Passos, Maria Elizabeth Pereira de Souza, Diego Ribeiro Gondim, Olivia Santos Benetti, Marino Levada-Pires, Adriana Cristina Ghorayeb, Nabil Kiss, Maria Augusta Peduti Dal Molin Gorjão, Renata Pithon-Curi, Tânia Cristina Cury-Boaventura, Maria Fernanda Marathon Race Affects Neutrophil Surface Molecules: Role of Inflammatory Mediators |
title | Marathon Race Affects Neutrophil Surface Molecules: Role of Inflammatory Mediators |
title_full | Marathon Race Affects Neutrophil Surface Molecules: Role of Inflammatory Mediators |
title_fullStr | Marathon Race Affects Neutrophil Surface Molecules: Role of Inflammatory Mediators |
title_full_unstemmed | Marathon Race Affects Neutrophil Surface Molecules: Role of Inflammatory Mediators |
title_short | Marathon Race Affects Neutrophil Surface Molecules: Role of Inflammatory Mediators |
title_sort | marathon race affects neutrophil surface molecules: role of inflammatory mediators |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135050/ https://www.ncbi.nlm.nih.gov/pubmed/27911915 http://dx.doi.org/10.1371/journal.pone.0166687 |
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