Tristetraprolin Down-Regulation Contributes to Persistent TNF-Alpha Expression Induced by Cigarette Smoke Extract through a Post-Transcriptional Mechanism

RATIONALE: Tumor necrosis factor-alpha (TNF-α) is a potent pro-inflammatory mediator and its expression is up-regulated in chronic obstructive pulmonary disease (COPD). Tristetraprolin (TTP) is implicated in regulation of TNF-α expression; however, whether TTP is involved in cigarette smoke-induced...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Xue-Ke, Che, Pulin, Cheng, Ming-Liang, Zhang, Quan, Mu, Mao, Li, Hong, Luo, Yuan, Liang, Yue-Dong, Luo, Xin-Hua, Gao, Chang-Qing, Jackson, Patricia L., Wells, J. Michael, Zhou, Yong, Hu, Meng, Cai, Guoqiang, Thannickal, Victor J., Steele, Chad, Blalock, J. Edwin, Han, Xiaosi, Chen, Ching-Yi, Ding, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135108/
https://www.ncbi.nlm.nih.gov/pubmed/27911957
http://dx.doi.org/10.1371/journal.pone.0167451

Ejemplares similares

Ejemplares similares