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Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract

Many neurodegenerative diseases are linked to amyloid aggregation. In Huntington’s disease (HD), neurotoxicity correlates with an increased aggregation propensity of a polyglutamine (polyQ) expansion in exon 1 of mutant huntingtin protein (mHtt). Here we establish how the domains flanking the polyQ...

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Detalles Bibliográficos
Autores principales:	Shen, Koning, Calamini, Barbara, Fauerbach, Jonathan A, Ma, Boxue, Shahmoradian, Sarah H, Serrano Lachapel, Ivana L, Chiu, Wah, Lo, Donald C, Frydman, Judith
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135392/ https://www.ncbi.nlm.nih.gov/pubmed/27751235 http://dx.doi.org/10.7554/eLife.18065

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