In Vitro and In Vivo Evaluation of (89)Zr-DS-8273a as a Theranostic for Anti-Death Receptor 5 Therapy

Background: DS-8273a, an anti-human death receptor 5 (DR5) agonistic antibody, has cytotoxic activity against human cancer cells and induces apoptosis after specific binding to DR5. DS-8273a is currently being used in clinical Phase I trials. This study evaluated the molecular imaging of DR5 express...

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Detalles Bibliográficos
Autores principales: Burvenich, Ingrid J.G., Lee, Fook-Thean, Guo, Nancy, Gan, Hui K., Rigopoulos, Angela, Parslow, Adam C., O'Keefe, Graeme J., Gong, Sylvia J., Tochon-Danguy, Henri, Rudd, Stacey E., Donnelly, Paul S., Kotsuma, Masakatsu, Ohtsuka, Toshiaki, Senaldi, Giorgio, Scott, Andrew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135445/
https://www.ncbi.nlm.nih.gov/pubmed/27924159
http://dx.doi.org/10.7150/thno.16260

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