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Aspergillus march: from ABPA to aspergilloma to subacute invasive aspergillosis

BACKGROUND: Aspergillus is a ubiquitous fungus responsible for allergic as well as saprophytic and invasive manifestations depending on host’s immune status. The following case report demonstrates progression of allergic manifestations of Aspergillus to its invasive form in an individual with decrea...

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Autores principales: Dogra, Vikas, Sinha, Ankit Kumar, Saxena, Rajat, Talwar, Deepak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135745/
https://www.ncbi.nlm.nih.gov/pubmed/27980539
http://dx.doi.org/10.1186/s13223-016-0170-9
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author Dogra, Vikas
Sinha, Ankit Kumar
Saxena, Rajat
Talwar, Deepak
author_facet Dogra, Vikas
Sinha, Ankit Kumar
Saxena, Rajat
Talwar, Deepak
author_sort Dogra, Vikas
collection PubMed
description BACKGROUND: Aspergillus is a ubiquitous fungus responsible for allergic as well as saprophytic and invasive manifestations depending on host’s immune status. The following case report demonstrates progression of allergic manifestations of Aspergillus to its invasive form in an individual with decreasing immunity. This can lead to uncertainties in diagnosis and management. CASE PRESENTATION: A 28-year-old male, non smoker, known case of ABPA (allergic bronchopulmonary aspergillosis) was admitted with complaints of cough for 1 month, associated with recurrent episodes of hemoptysis for last 5 days. CT Thorax revealed homogenous dense round opacity in right upper lobe which replaced previous fibrocalcific bronchiectatic lesion with cavity and aspergilloma, bulging across the major fissure with fibrotic strands extending to periphery in all directions. Post-pneumonectomy microscopic examination revealed Aspergillus hyphae invading blood vessels. CONCLUSION: There is a need for close clinical and radiologic follow up of patients with Aspergillus and our patient demonstrated overlap of complete spectrum of Aspergillus disease with march from one end to the other end.
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spelling pubmed-51357452016-12-15 Aspergillus march: from ABPA to aspergilloma to subacute invasive aspergillosis Dogra, Vikas Sinha, Ankit Kumar Saxena, Rajat Talwar, Deepak Allergy Asthma Clin Immunol Case Report BACKGROUND: Aspergillus is a ubiquitous fungus responsible for allergic as well as saprophytic and invasive manifestations depending on host’s immune status. The following case report demonstrates progression of allergic manifestations of Aspergillus to its invasive form in an individual with decreasing immunity. This can lead to uncertainties in diagnosis and management. CASE PRESENTATION: A 28-year-old male, non smoker, known case of ABPA (allergic bronchopulmonary aspergillosis) was admitted with complaints of cough for 1 month, associated with recurrent episodes of hemoptysis for last 5 days. CT Thorax revealed homogenous dense round opacity in right upper lobe which replaced previous fibrocalcific bronchiectatic lesion with cavity and aspergilloma, bulging across the major fissure with fibrotic strands extending to periphery in all directions. Post-pneumonectomy microscopic examination revealed Aspergillus hyphae invading blood vessels. CONCLUSION: There is a need for close clinical and radiologic follow up of patients with Aspergillus and our patient demonstrated overlap of complete spectrum of Aspergillus disease with march from one end to the other end. BioMed Central 2016-12-03 /pmc/articles/PMC5135745/ /pubmed/27980539 http://dx.doi.org/10.1186/s13223-016-0170-9 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Dogra, Vikas
Sinha, Ankit Kumar
Saxena, Rajat
Talwar, Deepak
Aspergillus march: from ABPA to aspergilloma to subacute invasive aspergillosis
title Aspergillus march: from ABPA to aspergilloma to subacute invasive aspergillosis
title_full Aspergillus march: from ABPA to aspergilloma to subacute invasive aspergillosis
title_fullStr Aspergillus march: from ABPA to aspergilloma to subacute invasive aspergillosis
title_full_unstemmed Aspergillus march: from ABPA to aspergilloma to subacute invasive aspergillosis
title_short Aspergillus march: from ABPA to aspergilloma to subacute invasive aspergillosis
title_sort aspergillus march: from abpa to aspergilloma to subacute invasive aspergillosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135745/
https://www.ncbi.nlm.nih.gov/pubmed/27980539
http://dx.doi.org/10.1186/s13223-016-0170-9
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