Cargando…

An immune stratification reveals a subset of PD-1/LAG-3 double-positive triple-negative breast cancers

BACKGROUND: Stromal tumor-infiltrating lymphocytes (TILs) are a robust prognostic factor in triple-negative breast cancer (TNBC). However, the clinical significance of TILs may be influenced by the complex landscape of the tumor immune microenvironment. In this study, we aimed to evaluate the compos...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bottai, Giulia, Raschioni, Carlotta, Losurdo, Agnese, Di Tommaso, Luca, Tinterri, Corrado, Torrisi, Rosalba, Reis-Filho, Jorge S., Roncalli, Massimo, Sotiriou, Christos, Santoro, Armando, Mantovani, Alberto, Loi, Sherene, Santarpia, Libero
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135782/ https://www.ncbi.nlm.nih.gov/pubmed/27912781 http://dx.doi.org/10.1186/s13058-016-0783-4

Ejemplares similares

CXCR4/CXCL12 Signaling and Protumor Macrophages in Primary Tumors and Sentinel Lymph Nodes Are Involved in Luminal B Breast Cancer Progression
por: Raschioni, Carlotta, et al.
Publicado: (2018)

AXL-associated tumor inflammation as a poor prognostic signature in chemotherapy-treated triple-negative breast cancer patients
por: Bottai, Giulia, et al.
Publicado: (2016)

Insights for the application of TILs and AR in the treatment of TNBC in routine clinical practice
por: Losurdo, Agnese, et al.
Publicado: (2020)

Targeting microRNAs as key modulators of tumor immune response
por: Paladini, Laura, et al.
Publicado: (2016)

Integrated MicroRNA–mRNA Profiling Identifies Oncostatin M as a Marker of Mesenchymal-Like ER-Negative/HER2-Negative Breast Cancer
por: Bottai, Giulia, et al.
Publicado: (2017)

Never too old to fight breast cancer: A case report
por: Zuradelli, Monica, et al.
Publicado: (2018)

Single-cell profiling defines the prognostic benefit of CD39(high) tissue resident memory CD8+ T cells in luminal-like breast cancer
por: Losurdo, Agnese, et al.
Publicado: (2021)

Author Correction: Single-cell profiling defines the prognostic benefit of CD39(high) tissue resident memory CD8+ T cells in luminal-like breast cancer
por: Losurdo, Agnese, et al.
Publicado: (2021)

Gene Expression Profiling in Early Breast Cancer—Patient Stratification Based on Molecular and Tumor Microenvironment Features
por: Munkácsy, Gyöngyi, et al.
Publicado: (2022)

MicroRNA-21 links epithelial-to-mesenchymal transition and inflammatory signals to confer resistance to neoadjuvant trastuzumab and chemotherapy in HER2-positive breast cancer patients
por: De Mattos-Arruda, Leticia, et al.
Publicado: (2015)

Clinical predictors of cardiac toxicity in HER2-positive early breast cancer patients treated with adjuvant s.c. versus i.v. trastuzumab
por: De Sanctis, Rita, et al.
Publicado: (2021)

One-Step Nucleic Acid Amplification in Breast Cancer Sentinel Lymph Node: A Single Institutional Experience and a Short Review
por: Brambilla, Tatiana, et al.
Publicado: (2015)

HR(+)/HER2(−) de novo metastatic breast cancer: a true peculiar entity?
por: Torrisi, Rosalba, et al.
Publicado: (2023)

An integrative bioinformatics approach reveals coding and non-coding gene variants associated with gene expression profiles and outcome in breast cancer molecular subtypes
por: Győrffy, Balázs, et al.
Publicado: (2018)

Feasibility of developing reliable gene expression modules from FFPE derived RNA profiled on Affymetrix arrays
por: Jose, Vinu, et al.
Publicado: (2018)

Low-dose “metronomic chemotherapy” with oral cyclophosphamide and methotrexate in metastatic breast cancer: a case report of extraordinarily prolonged clinical benefit
por: Masci, G, et al.
Publicado: (2012)

Therapeutic Potential of Tumor Metabolic Reprogramming in Triple-Negative Breast Cancer
por: Munkácsy, Gyöngyi, et al.
Publicado: (2023)

Tumor-infiltrating lymphocytes, breast cancer subtypes and therapeutic efficacy
por: Loi, Sherene
Publicado: (2013)

Tumor infiltrating lymphocyte stratification of prognostic staging of early-stage triple negative breast cancer
por: Loi, Sherene, et al.
Publicado: (2022)

Sticking to the Rules: Outcome and Success Rate of Guideline-Based Diarrhea Management in Metastatic Breast Cancer Patients Treated with Abemaciclib
por: Jacobs, Flavia, et al.
Publicado: (2023)

Author response to: Redefining axillary lymph node dissection in mastectomy: insights from the SINODAR-ONE study
por: Gentile, Damiano, et al.
Publicado: (2023)

Cellular Signaling Pathway Alterations and Potential Targeted Therapies for Medullary Thyroid Carcinoma
por: Giunti, Serena, et al.
Publicado: (2013)

Mosaicism in von Hippel-Lindau disease: an event important to recognize
por: Santarpia, Libero, et al.
Publicado: (2007)

Clinical Review on the Management of Breast Cancer Visceral Crisis
por: Benvenuti, Chiara, et al.
Publicado: (2023)

Phase I-II study of hypofractionated simultaneous integrated boost using volumetric modulated arc therapy for adjuvant radiation therapy in breast cancer patients: a report of feasibility and early toxicity results in the first 50 treatments
por: Scorsetti, Marta, et al.
Publicado: (2012)

Metastases from Occult Breast Cancer: A Case Report of Carcinoma of Unknown Primary Syndrome
por: Barbieri, Erika, et al.
Publicado: (2020)

Triple-negative breast cancer: recent treatment advances
por: Bergin, Alice R T, et al.
Publicado: (2019)

Immune checkpoint inhibition in the treatment of early stage triple negative breast cancer: 2021 update()
por: Brown, Lauren C., et al.
Publicado: (2021)

Immunotherapy in Early-Stage Triple-Negative Breast Cancer: Where Are We Now and Where Are We Headed?
por: Dixon-Douglas, Julia, et al.
Publicado: (2023)

Profiling the Spectrum of Headache Disorders on 440 Breast Cancer Patients: Highlights on Clinical and Pathological Mechanisms
por: Ilieva, Mariya Boyanova, et al.
Publicado: (2023)

Gene expression profiling identifies activated growth factor signaling in poor prognosis (Luminal-B) estrogen receptor positive breast cancer
por: Loi, Sherene, et al.
Publicado: (2009)

Correlation between subsets of tumor-infiltrating immune cells and risk stratification in patients with cervical cancer
por: Chen, Rui, et al.
Publicado: (2019)

RANK-ligand (RANKL) expression in young breast cancer patients and during pregnancy
por: Azim, Hatem A, et al.
Publicado: (2015)

NEONOD 2: Rationale and design of a multicenter non-inferiority trial to assess the effect of axillary surgery omission on the outcome of breast cancer patients presenting only micrometastasis in the sentinel lymph node after neoadjuvant chemotherapy
por: Tinterri, Corrado, et al.
Publicado: (2019)

ScanLag: High-throughput Quantification of Colony Growth and Lag Time
por: Levin-Reisman, Irit, et al.
Publicado: (2014)

The expression profiles of signature genes from CD103(+)LAG3(+) tumour-infiltrating lymphocyte subsets predict breast cancer survival
por: Xia, Zi-An, et al.
Publicado: (2023)

PIK3CA mutations in breast cancer: reconciling findings from preclinical and clinical data
por: Zardavas, Dimitrios, et al.
Publicado: (2014)

Residual disease and immune infiltration as a new surrogate endpoint for TNBC post neoadjuvant chemotherapy
por: Luen, Stephen L., et al.
Publicado: (2019)

Jet Lag in Athletes
por: Lee, Aaron, et al.
Publicado: (2012)

Is Prosthetic Dentistry Lagging?: No
por: Trueman, William H.
Publicado: (1894)

Cannot write session to /tmp/vufind_sessions/sess_8r10n3hq04tud08ftec29q9mjn