Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

Mutations of the tricarboxylic acid cycle (TCA cycle) enzyme fumarate hydratase (FH) cause Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC)1. FH-deficient renal cancers are highly aggressive and metastasise even when small, leading to an abysmal clinical outcome2. Fumarate, a small molecule m...

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Detalles Bibliográficos
Autores principales: Sciacovelli, Marco, Gonçalves, Emanuel, Isaac Johnson, Timothy, Roberto Zecchini, Vincent, da Costa, Ana Sofia Henriques, Gaude, Edoardo, Vercauteren Drubbel, Alizee, Julian Theobald, Sebastian, Abbo, Sandra, Tran, Maxine, Rajeeve, Vinothini, Cardaci, Simone, Foster, Sarah, Yun, Haiyang, Cutillas, Pedro, Warren, Anne, Gnanapragasam, Vincent, Gottlieb, Eyal, Franze, Kristian, Huntly, Brian, Richard Maher, Eamonn, Henry Maxwell, Patrick, Saez-Rodriguez, Julio, Frezza, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136292/
https://www.ncbi.nlm.nih.gov/pubmed/27580029
http://dx.doi.org/10.1038/nature19353

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