Cargando…

Activation of NMDA receptors and the mechanism of inhibition by ifenprodil

The physiology of N-Methyl-D-aspartate (NMDA) receptors in mammals is fundamental to brain development and function. NMDA receptors are ionotropic glutamate receptors that function as heterotetramers composed mainly of GluN1 and GluN2 subunits. Activation of NMDA receptors requires binding of neurot...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tajima, Nami, Karakas, Erkan, Grant, Timothy, Simorowski, Noriko, Diaz-Avalos, Ruben, Grigorieff, Nikolaus, Furukawa, Hiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136294/ https://www.ncbi.nlm.nih.gov/pubmed/27135925 http://dx.doi.org/10.1038/nature17679

Ejemplares similares

Subunit Arrangement and Phenylethanolamine Binding in GluN1/GluN2B NMDA Receptors
por: Karakas, Erkan, et al.
Publicado: (2011)

Development and characterization of functional antibodies targeting NMDA receptors
por: Tajima, Nami, et al.
Publicado: (2022)

A conserved structural mechanism of NMDA receptor inhibition: A comparison of ifenprodil and zinc
por: Sirrieh, Rita E., et al.
Publicado: (2015)

Structure and assembly of calcium homeostasis modulator proteins
por: Syrjanen, Johanna L, et al.
Publicado: (2020)

Structural insights into NMDA receptor pharmacology
por: Zhou, Changping, et al.
Publicado: (2023)

Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors
por: Wang, Jue Xiang, et al.
Publicado: (2020)

Mechanism of ribosome rescue by ArfA and RF2
por: Demo, Gabriel, et al.
Publicado: (2017)

Moderate Prenatal Alcohol Exposure Enhances GluN2B Containing NMDA Receptor Binding and Ifenprodil Sensitivity in Rat Agranular Insular Cortex
por: Bird, Clark W., et al.
Publicado: (2015)

Exploring the overlapping binding sites of ifenprodil and EVT‐101 in GluN2B‐containing NMDA receptors using novel chicken embryo forebrain cultures and molecular modeling
por: Fjelldal, Marthe F., et al.
Publicado: (2019)

Cytotoxicity Profiles and Neuroprotective Properties of the Novel Ifenprodil Analogues as Sigma Ligands
por: Zampieri, Daniele, et al.
Publicado: (2023)

Excitatory and inhibitory D-serine binding to the NMDA receptor
por: Yovanno, Remy A, et al.
Publicado: (2022)

Structure, function, and allosteric modulation of NMDA receptors
por: Hansen, Kasper B., et al.
Publicado: (2018)

GluN2A‐Selective NMDA Receptor Antagonists: Mimicking the U‐Shaped Bioactive Conformation of TCN‐201 by a [2.2]Paracyclophane System
por: Steigerwald, Ruben, et al.
Publicado: (2022)

Measuring the optimal exposure for single particle cryo-EM using a 2.6 Å reconstruction of rotavirus VP6
por: Grant, Timothy, et al.
Publicado: (2015)

Anti-epileptic effect of ifenprodil on neocortical pyramidal neurons in patients with malformations of cortical development
por: Wang, Xiongfei, et al.
Publicado: (2017)

A randomized controlled study of the effect of ifenprodil on alcohol use in patients with alcohol dependence
por: Sugaya, Nagisa, et al.
Publicado: (2018)

Ifenprodil for the treatment of methamphetamine use disorder: An exploratory, randomized, double‐blind, placebo‐controlled trial
por: Kotajima‐Murakami, Hiroko, et al.
Publicado: (2022)

cisTEM, user-friendly software for single-particle image processing
por: Grant, Timothy, et al.
Publicado: (2018)

Divergent roles of a peripheral transmembrane segment in AMPA and NMDA receptors
por: Amin, Johansen B., et al.
Publicado: (2017)

Potentiation of Nerve Growth Factor-Induced Neurite Outgrowth in PC12 Cells by Ifenprodil: The Role of Sigma-1 and IP(3) Receptors
por: Ishima, Tamaki, et al.
Publicado: (2012)

Effect of the ifenprodil administered into rostral anterior cingulate cortex on pain-related aversion in rats with bone cancer pain
por: Feng, Hao, et al.
Publicado: (2016)

Study of effects of ifenprodil in patients with methamphetamine dependence: Protocol for an exploratory, randomized, double‐blind, placebo‐controlled trial
por: Kotajima‐Murakami, Hiroko, et al.
Publicado: (2019)

Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors
por: Regan, Michael C., et al.
Publicado: (2019)

Structure of the Vesicular Stomatitis Virus L Protein in Complex with Its Phosphoprotein Cofactor
por: Jenni, Simon, et al.
Publicado: (2020)

Mechanisms of NMDA Receptor Inhibition by Sepimostat—Comparison with Nafamostat and Diarylamidine Compounds
por: Zhigulin, Arseniy S., et al.
Publicado: (2023)

N-retinylidene-N-retinylethanolamine degradation in human retinal pigment epithelial cells via memantine- and ifenprodil-mediated autophagy
por: Lee, Jae Rim, et al.
Publicado: (2023)

Structure of RNA polymerase bound to ribosomal 30S subunit
por: Demo, Gabriel, et al.
Publicado: (2017)

Role of the NMDA-receptor in Prepulse Inhibition in the Rat
por: Linderholm, Klas, et al.
Publicado: (2010)

Direct detection pays off for electron cryo-microscopy
por: Grigorieff, Nikolaus
Publicado: (2013)

Supramolecular organization of NMDA receptors and the postsynaptic density
por: Frank, René AW, et al.
Publicado: (2017)

Prion protein attenuates excitotoxicity by inhibiting NMDA receptors
por: Khosravani, Houman, et al.
Publicado: (2008)

Prion protein attenuates excitotoxicity by inhibiting NMDA receptors
por: Khosravani, Houman, et al.
Publicado: (2009)

Increased NMDA receptor inhibition at an increased Sevoflurane MAC
por: Brosnan, Robert J, et al.
Publicado: (2012)

Mechanical stress activates NMDA receptors in the absence of agonists
por: Maneshi, Mohammad Mehdi, et al.
Publicado: (2017)

Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome
por: Abeyrathne, Priyanka D, et al.
Publicado: (2016)

NMDA-receptor-Fc-fusion constructs neutralize anti-NMDA receptor antibodies
por: Steinke, Stephan, et al.
Publicado: (2023)

Ensemble cryo-EM elucidates the mechanism of translation fidelity
por: Loveland, Anna B., et al.
Publicado: (2017)

Distinct regulation of tonic GABAergic inhibition by NMDA receptor subtypes
por: Wu, Kunwei, et al.
Publicado: (2021)

Inhibition of NMDA receptors through a membrane-to-channel path
por: Wilcox, Madeleine R., et al.
Publicado: (2022)

Molecular Machines: Putting the Pieces Together
por: Nogales, Eva, et al.
Publicado: (2001)

Cannot write session to /tmp/vufind_sessions/sess_2he8episi84lb9qeaoibudqmpr