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Evaluation of Wound Healing Properties of Grape Seed, Sesame, and Fenugreek Oils

Background. Medicinal plants have proved at all times to be a powerful remedy for health care. Accordingly, grape seed, sesame, and fenugreek extracted oils with pharmacological properties are investigated as wound treatments. This study assesses the potential of our oils for healing wounds induced...

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Autores principales: Moalla Rekik, Dorsaf, Ben Khedir, Sameh, Ksouda Moalla, Kamilia, Kammoun, Naziha Grati, Rebai, Tarek, Sahnoun, Zouheir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136421/
https://www.ncbi.nlm.nih.gov/pubmed/27990170
http://dx.doi.org/10.1155/2016/7965689
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author Moalla Rekik, Dorsaf
Ben Khedir, Sameh
Ksouda Moalla, Kamilia
Kammoun, Naziha Grati
Rebai, Tarek
Sahnoun, Zouheir
author_facet Moalla Rekik, Dorsaf
Ben Khedir, Sameh
Ksouda Moalla, Kamilia
Kammoun, Naziha Grati
Rebai, Tarek
Sahnoun, Zouheir
author_sort Moalla Rekik, Dorsaf
collection PubMed
description Background. Medicinal plants have proved at all times to be a powerful remedy for health care. Accordingly, grape seed, sesame, and fenugreek extracted oils with pharmacological properties are investigated as wound treatments. This study assesses the potential of our oils for healing wounds induced on rats. Methods. Phytochemical analyses of oils have involved: quality value, polyphenol, chlorophylls, carotene, and fatty acids. Antibacterial activity was carried out. Antioxidant activity was evaluated: the scavenging effect on DPPH radicals, the reducing power, and β-carotene discoloration. Uniform wound excision was induced on rats dorsum randomly divided into five groups: groups treated with “CICAFLORA®” and tested oils and untreated one. The posthealing biopsies were histologically assessed. Results. Wound biopsies treated with oils showed the best tissue regeneration compared to control groups. Groups treated with our oils and “CICAFLORA” had higher wound contraction percentage. Polyunsaturated fatty acids in oils act as inflammatory mediators increasing neovascularization, extracellular remodeling, migration, and cell differentiation. Wound healing effect was attributed to antibacterial and antioxidant synergy. Conclusion. According to findings, oils showed better activity in wound healing compared to “CICAFLORA” due to a phytoconstituents synergy. However, clinical trials on humans are necessary to confirm efficacy on human pathology.
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spelling pubmed-51364212016-12-18 Evaluation of Wound Healing Properties of Grape Seed, Sesame, and Fenugreek Oils Moalla Rekik, Dorsaf Ben Khedir, Sameh Ksouda Moalla, Kamilia Kammoun, Naziha Grati Rebai, Tarek Sahnoun, Zouheir Evid Based Complement Alternat Med Research Article Background. Medicinal plants have proved at all times to be a powerful remedy for health care. Accordingly, grape seed, sesame, and fenugreek extracted oils with pharmacological properties are investigated as wound treatments. This study assesses the potential of our oils for healing wounds induced on rats. Methods. Phytochemical analyses of oils have involved: quality value, polyphenol, chlorophylls, carotene, and fatty acids. Antibacterial activity was carried out. Antioxidant activity was evaluated: the scavenging effect on DPPH radicals, the reducing power, and β-carotene discoloration. Uniform wound excision was induced on rats dorsum randomly divided into five groups: groups treated with “CICAFLORA®” and tested oils and untreated one. The posthealing biopsies were histologically assessed. Results. Wound biopsies treated with oils showed the best tissue regeneration compared to control groups. Groups treated with our oils and “CICAFLORA” had higher wound contraction percentage. Polyunsaturated fatty acids in oils act as inflammatory mediators increasing neovascularization, extracellular remodeling, migration, and cell differentiation. Wound healing effect was attributed to antibacterial and antioxidant synergy. Conclusion. According to findings, oils showed better activity in wound healing compared to “CICAFLORA” due to a phytoconstituents synergy. However, clinical trials on humans are necessary to confirm efficacy on human pathology. Hindawi Publishing Corporation 2016 2016-11-20 /pmc/articles/PMC5136421/ /pubmed/27990170 http://dx.doi.org/10.1155/2016/7965689 Text en Copyright © 2016 Dorsaf Moalla Rekik et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Moalla Rekik, Dorsaf
Ben Khedir, Sameh
Ksouda Moalla, Kamilia
Kammoun, Naziha Grati
Rebai, Tarek
Sahnoun, Zouheir
Evaluation of Wound Healing Properties of Grape Seed, Sesame, and Fenugreek Oils
title Evaluation of Wound Healing Properties of Grape Seed, Sesame, and Fenugreek Oils
title_full Evaluation of Wound Healing Properties of Grape Seed, Sesame, and Fenugreek Oils
title_fullStr Evaluation of Wound Healing Properties of Grape Seed, Sesame, and Fenugreek Oils
title_full_unstemmed Evaluation of Wound Healing Properties of Grape Seed, Sesame, and Fenugreek Oils
title_short Evaluation of Wound Healing Properties of Grape Seed, Sesame, and Fenugreek Oils
title_sort evaluation of wound healing properties of grape seed, sesame, and fenugreek oils
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136421/
https://www.ncbi.nlm.nih.gov/pubmed/27990170
http://dx.doi.org/10.1155/2016/7965689
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