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Parameter Identifiability of Fundamental Pharmacodynamic Models

Issues of parameter identifiability of routinely used pharmacodynamics models are considered in this paper. The structural identifiability of 16 commonly applied pharmacodynamic model structures was analyzed analytically, using the input-output approach. Both fixed-effects versions (non-population,...

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Detalles Bibliográficos
Autores principales:	Janzén, David L. I., Bergenholm, Linnéa, Jirstrand, Mats, Parkinson, Joanna, Yates, James, Evans, Neil D., Chappell, Michael J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136565/ https://www.ncbi.nlm.nih.gov/pubmed/27994553 http://dx.doi.org/10.3389/fphys.2016.00590

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