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Diagnostic Accuracy of Robot-Guided, Software Based Transperineal MRI/TRUS Fusion Biopsy of the Prostate in a High Risk Population of Previously Biopsy Negative Men
Objective. In this study, we compared prostate cancer detection rates between MRI-TRUS fusion targeted and systematic biopsies using a robot-guided, software based transperineal approach. Methods and Patients. 52 patients received a MRIT/TRUS fusion followed by a systematic volume adapted biopsy usi...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136643/ https://www.ncbi.nlm.nih.gov/pubmed/27990424 http://dx.doi.org/10.1155/2016/2384894 |
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author | Kroenig, Malte Schaal, Kathrin Benndorf, Matthias Soschynski, Martin Lenz, Philipp Krauss, Tobias Drendel, Vanessa Kayser, Gian Kurz, Philipp Werner, Martin Wetterauer, Ulrich Schultze-Seemann, Wolfgang Langer, Mathias Jilg, Cordula A. |
author_facet | Kroenig, Malte Schaal, Kathrin Benndorf, Matthias Soschynski, Martin Lenz, Philipp Krauss, Tobias Drendel, Vanessa Kayser, Gian Kurz, Philipp Werner, Martin Wetterauer, Ulrich Schultze-Seemann, Wolfgang Langer, Mathias Jilg, Cordula A. |
author_sort | Kroenig, Malte |
collection | PubMed |
description | Objective. In this study, we compared prostate cancer detection rates between MRI-TRUS fusion targeted and systematic biopsies using a robot-guided, software based transperineal approach. Methods and Patients. 52 patients received a MRIT/TRUS fusion followed by a systematic volume adapted biopsy using the same robot-guided transperineal approach. The primary outcome was the detection rate of clinically significant disease (Gleason grade ≥ 4). Secondary outcomes were detection rate of all cancers, sampling efficiency and utility, and serious adverse event rate. Patients received no antibiotic prophylaxis. Results. From 52 patients, 519 targeted biopsies from 135 lesions and 1561 random biopsies were generated (total n = 2080). Overall detection rate of clinically significant PCa was 44.2% (23/52) and 50.0% (26/52) for target and random biopsy, respectively. Sampling efficiency as the median number of cores needed to detect clinically significant prostate cancer was 9 for target (IQR: 6–14.0) and 32 (IQR: 24–32) for random biopsy. The utility as the number of additionally detected clinically significant PCa cases by either strategy was 0% (0/52) for target and 3.9% (2/52) for random biopsy. Conclusions. MRI/TRUS fusion based target biopsy did not show an advantage in the overall detection rate of clinically significant prostate cancer. |
format | Online Article Text |
id | pubmed-5136643 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-51366432016-12-18 Diagnostic Accuracy of Robot-Guided, Software Based Transperineal MRI/TRUS Fusion Biopsy of the Prostate in a High Risk Population of Previously Biopsy Negative Men Kroenig, Malte Schaal, Kathrin Benndorf, Matthias Soschynski, Martin Lenz, Philipp Krauss, Tobias Drendel, Vanessa Kayser, Gian Kurz, Philipp Werner, Martin Wetterauer, Ulrich Schultze-Seemann, Wolfgang Langer, Mathias Jilg, Cordula A. Biomed Res Int Research Article Objective. In this study, we compared prostate cancer detection rates between MRI-TRUS fusion targeted and systematic biopsies using a robot-guided, software based transperineal approach. Methods and Patients. 52 patients received a MRIT/TRUS fusion followed by a systematic volume adapted biopsy using the same robot-guided transperineal approach. The primary outcome was the detection rate of clinically significant disease (Gleason grade ≥ 4). Secondary outcomes were detection rate of all cancers, sampling efficiency and utility, and serious adverse event rate. Patients received no antibiotic prophylaxis. Results. From 52 patients, 519 targeted biopsies from 135 lesions and 1561 random biopsies were generated (total n = 2080). Overall detection rate of clinically significant PCa was 44.2% (23/52) and 50.0% (26/52) for target and random biopsy, respectively. Sampling efficiency as the median number of cores needed to detect clinically significant prostate cancer was 9 for target (IQR: 6–14.0) and 32 (IQR: 24–32) for random biopsy. The utility as the number of additionally detected clinically significant PCa cases by either strategy was 0% (0/52) for target and 3.9% (2/52) for random biopsy. Conclusions. MRI/TRUS fusion based target biopsy did not show an advantage in the overall detection rate of clinically significant prostate cancer. Hindawi Publishing Corporation 2016 2016-11-21 /pmc/articles/PMC5136643/ /pubmed/27990424 http://dx.doi.org/10.1155/2016/2384894 Text en Copyright © 2016 Malte Kroenig et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Kroenig, Malte Schaal, Kathrin Benndorf, Matthias Soschynski, Martin Lenz, Philipp Krauss, Tobias Drendel, Vanessa Kayser, Gian Kurz, Philipp Werner, Martin Wetterauer, Ulrich Schultze-Seemann, Wolfgang Langer, Mathias Jilg, Cordula A. Diagnostic Accuracy of Robot-Guided, Software Based Transperineal MRI/TRUS Fusion Biopsy of the Prostate in a High Risk Population of Previously Biopsy Negative Men |
title | Diagnostic Accuracy of Robot-Guided, Software Based Transperineal MRI/TRUS Fusion Biopsy of the Prostate in a High Risk Population of Previously Biopsy Negative Men |
title_full | Diagnostic Accuracy of Robot-Guided, Software Based Transperineal MRI/TRUS Fusion Biopsy of the Prostate in a High Risk Population of Previously Biopsy Negative Men |
title_fullStr | Diagnostic Accuracy of Robot-Guided, Software Based Transperineal MRI/TRUS Fusion Biopsy of the Prostate in a High Risk Population of Previously Biopsy Negative Men |
title_full_unstemmed | Diagnostic Accuracy of Robot-Guided, Software Based Transperineal MRI/TRUS Fusion Biopsy of the Prostate in a High Risk Population of Previously Biopsy Negative Men |
title_short | Diagnostic Accuracy of Robot-Guided, Software Based Transperineal MRI/TRUS Fusion Biopsy of the Prostate in a High Risk Population of Previously Biopsy Negative Men |
title_sort | diagnostic accuracy of robot-guided, software based transperineal mri/trus fusion biopsy of the prostate in a high risk population of previously biopsy negative men |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136643/ https://www.ncbi.nlm.nih.gov/pubmed/27990424 http://dx.doi.org/10.1155/2016/2384894 |
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