Pan PPAR agonist IVA337 is effective in prevention and treatment of experimental skin fibrosis

BACKGROUND: The pathogenesis of systemic sclerosis (SSc) involves a distinctive triad of autoimmune, vascular and inflammatory alterations resulting in fibrosis. Evidence suggests that peroxisome proliferator-activated receptors (PPARs) play an important role in SSc-related fibrosis and their agonis...

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Detalles Bibliográficos
Autores principales: Ruzehaji, Nadira, Frantz, Camelia, Ponsoye, Matthieu, Avouac, Jerome, Pezet, Sonia, Guilbert, Thomas, Luccarini, Jean-Michel, Broqua, Pierre, Junien, Jean-Louis, Allanore, Yannick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Basic and Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136696/
https://www.ncbi.nlm.nih.gov/pubmed/26961294
http://dx.doi.org/10.1136/annrheumdis-2015-208029

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