PKCδ null mutations in a mouse model of osteoarthritis alter osteoarthritic pain independently of joint pathology by augmenting NGF/TrkA-induced axonal outgrowth

OBJECTIVES: A key clinical paradox in osteoarthritis (OA), a prevalent age-related joint disorder characterised by cartilage degeneration and debilitating pain, is that the severity of joint pain does not strictly correlate with radiographic and histological defects in joint tissues. Here, we determ...

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Detalles Bibliográficos
Autores principales: Kc, Ranjan, Li, Xin, Kroin, Jeffrey S, Liu, Zhiqiang, Chen, Di, Xiao, Guozhi, Levine, Brett, Li, Jinyuan, Hamilton, John L, van Wijnen, Andre J, Piel, Margaret, Shelly, Daniel A, Brass, Dovrat, Kolb, Ela, Im, Hee-Jeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Basic and Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136703/
https://www.ncbi.nlm.nih.gov/pubmed/26783110
http://dx.doi.org/10.1136/annrheumdis-2015-208444

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