Dysregulation of the intrinsic apoptotic pathway mediates megakaryocytic hyperplasia in myeloproliferative neoplasms

AIMS: Megakaryocyte expansion in myeloproliferative neoplasms (MPNs) is due to uncontrolled proliferation accompanied by dysregulation of proapoptotic and antiapoptotic mechanisms. Here we have investigated the intrinsic and extrinsic apoptotic pathways of megakaryocytes in human MPNs to further def...

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Detalles Bibliográficos
Autores principales: Malherbe, Jacques A J, Fuller, Kathryn A, Mirzai, Bob, Kavanagh, Simon, So, Chi-Chiu, Ip, Ho-Wan, Guo, Belinda B, Forsyth, Cecily, Howman, Rebecca, Erber, Wendy N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136711/
https://www.ncbi.nlm.nih.gov/pubmed/27060176
http://dx.doi.org/10.1136/jclinpath-2016-203625

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