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A Novel Role of Lamins from Genetic Disease to Cancer Biomarkers

Lamins are the key components of the nuclear lamina and by virtue of their interactions with chromatin and binding partners act as regulators of cell proliferation and differentiation. Of late, the diverse roles of lamins in cellular processes have made them the topic of intense debate for their rol...

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Autores principales: Sakthivel, Kunnathur Murugesan, Sehgal, Poonam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136755/
https://www.ncbi.nlm.nih.gov/pubmed/27994771
http://dx.doi.org/10.4081/oncol.2016.309
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author Sakthivel, Kunnathur Murugesan
Sehgal, Poonam
author_facet Sakthivel, Kunnathur Murugesan
Sehgal, Poonam
author_sort Sakthivel, Kunnathur Murugesan
collection PubMed
description Lamins are the key components of the nuclear lamina and by virtue of their interactions with chromatin and binding partners act as regulators of cell proliferation and differentiation. Of late, the diverse roles of lamins in cellular processes have made them the topic of intense debate for their role in cancer progression. The observations about aberrant localization or misexpression of the nuclear lamins in cancerous tissues have often led to the speculative role of lamins as a cancer risk biomarker. Here we discuss the involvement of lamins in several cancer subtypes and their potential role in predicting the tumor progression.
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spelling pubmed-51367552016-12-19 A Novel Role of Lamins from Genetic Disease to Cancer Biomarkers Sakthivel, Kunnathur Murugesan Sehgal, Poonam Oncol Rev Review Lamins are the key components of the nuclear lamina and by virtue of their interactions with chromatin and binding partners act as regulators of cell proliferation and differentiation. Of late, the diverse roles of lamins in cellular processes have made them the topic of intense debate for their role in cancer progression. The observations about aberrant localization or misexpression of the nuclear lamins in cancerous tissues have often led to the speculative role of lamins as a cancer risk biomarker. Here we discuss the involvement of lamins in several cancer subtypes and their potential role in predicting the tumor progression. PAGEPress Publications, Pavia, Italy 2016-11-14 /pmc/articles/PMC5136755/ /pubmed/27994771 http://dx.doi.org/10.4081/oncol.2016.309 Text en ©Copyright K.M. Sakthivel and P. Sehgal http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Sakthivel, Kunnathur Murugesan
Sehgal, Poonam
A Novel Role of Lamins from Genetic Disease to Cancer Biomarkers
title A Novel Role of Lamins from Genetic Disease to Cancer Biomarkers
title_full A Novel Role of Lamins from Genetic Disease to Cancer Biomarkers
title_fullStr A Novel Role of Lamins from Genetic Disease to Cancer Biomarkers
title_full_unstemmed A Novel Role of Lamins from Genetic Disease to Cancer Biomarkers
title_short A Novel Role of Lamins from Genetic Disease to Cancer Biomarkers
title_sort novel role of lamins from genetic disease to cancer biomarkers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136755/
https://www.ncbi.nlm.nih.gov/pubmed/27994771
http://dx.doi.org/10.4081/oncol.2016.309
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