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A Novel Role of Lamins from Genetic Disease to Cancer Biomarkers
Lamins are the key components of the nuclear lamina and by virtue of their interactions with chromatin and binding partners act as regulators of cell proliferation and differentiation. Of late, the diverse roles of lamins in cellular processes have made them the topic of intense debate for their rol...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PAGEPress Publications, Pavia, Italy
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136755/ https://www.ncbi.nlm.nih.gov/pubmed/27994771 http://dx.doi.org/10.4081/oncol.2016.309 |
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author | Sakthivel, Kunnathur Murugesan Sehgal, Poonam |
author_facet | Sakthivel, Kunnathur Murugesan Sehgal, Poonam |
author_sort | Sakthivel, Kunnathur Murugesan |
collection | PubMed |
description | Lamins are the key components of the nuclear lamina and by virtue of their interactions with chromatin and binding partners act as regulators of cell proliferation and differentiation. Of late, the diverse roles of lamins in cellular processes have made them the topic of intense debate for their role in cancer progression. The observations about aberrant localization or misexpression of the nuclear lamins in cancerous tissues have often led to the speculative role of lamins as a cancer risk biomarker. Here we discuss the involvement of lamins in several cancer subtypes and their potential role in predicting the tumor progression. |
format | Online Article Text |
id | pubmed-5136755 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | PAGEPress Publications, Pavia, Italy |
record_format | MEDLINE/PubMed |
spelling | pubmed-51367552016-12-19 A Novel Role of Lamins from Genetic Disease to Cancer Biomarkers Sakthivel, Kunnathur Murugesan Sehgal, Poonam Oncol Rev Review Lamins are the key components of the nuclear lamina and by virtue of their interactions with chromatin and binding partners act as regulators of cell proliferation and differentiation. Of late, the diverse roles of lamins in cellular processes have made them the topic of intense debate for their role in cancer progression. The observations about aberrant localization or misexpression of the nuclear lamins in cancerous tissues have often led to the speculative role of lamins as a cancer risk biomarker. Here we discuss the involvement of lamins in several cancer subtypes and their potential role in predicting the tumor progression. PAGEPress Publications, Pavia, Italy 2016-11-14 /pmc/articles/PMC5136755/ /pubmed/27994771 http://dx.doi.org/10.4081/oncol.2016.309 Text en ©Copyright K.M. Sakthivel and P. Sehgal http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Sakthivel, Kunnathur Murugesan Sehgal, Poonam A Novel Role of Lamins from Genetic Disease to Cancer Biomarkers |
title | A Novel Role of Lamins from Genetic Disease to Cancer Biomarkers |
title_full | A Novel Role of Lamins from Genetic Disease to Cancer Biomarkers |
title_fullStr | A Novel Role of Lamins from Genetic Disease to Cancer Biomarkers |
title_full_unstemmed | A Novel Role of Lamins from Genetic Disease to Cancer Biomarkers |
title_short | A Novel Role of Lamins from Genetic Disease to Cancer Biomarkers |
title_sort | novel role of lamins from genetic disease to cancer biomarkers |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136755/ https://www.ncbi.nlm.nih.gov/pubmed/27994771 http://dx.doi.org/10.4081/oncol.2016.309 |
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