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Inhibition of alpha-synuclein aggregation by multifunctional dopamine agonists assessed by a novel in vitro assay and an in vivo Drosophila synucleinopathy model

Aggregation of alpha synuclein (α-syn) leading to dopaminergic neuronal death has been recognized as one of the main pathogenic factors in the initiation and progression of Parkinson’s disease (PD). Consequently, α-syn has been targeted for the development of therapeutics for PD. We have developed a...

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Detalles Bibliográficos
Autores principales:	Yedlapudi, Deepthi, Joshi, Gnanada S., Luo, Dan, Todi, Sokol V., Dutta, Aloke K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137034/ https://www.ncbi.nlm.nih.gov/pubmed/27917933 http://dx.doi.org/10.1038/srep38510

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