Cargando…

Association of Cortical Vein Filling with Clot Location and Clinical Outcomes in Acute Ischaemic Stroke Patients

Delay in cortical vein filling during the late-venous phase (delayed-LCVF) is characterized by opacification of cerebral veins despite contrast clearance from contralateral veins on dynamic computed tomography angiography (dCTA) in acute ischemic stroke (AIS) patients. The aim of the study was to in...

Descripción completa

Detalles Bibliográficos
Autores principales: Bhaskar, Sonu, Bivard, Andrew, Stanwell, Peter, Attia, John R., Parsons, Mark, Nilsson, Michael, Levi, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137111/
https://www.ncbi.nlm.nih.gov/pubmed/27917948
http://dx.doi.org/10.1038/srep38525
_version_ 1782471849033072640
author Bhaskar, Sonu
Bivard, Andrew
Stanwell, Peter
Attia, John R.
Parsons, Mark
Nilsson, Michael
Levi, Christopher
author_facet Bhaskar, Sonu
Bivard, Andrew
Stanwell, Peter
Attia, John R.
Parsons, Mark
Nilsson, Michael
Levi, Christopher
author_sort Bhaskar, Sonu
collection PubMed
description Delay in cortical vein filling during the late-venous phase (delayed-LCVF) is characterized by opacification of cerebral veins despite contrast clearance from contralateral veins on dynamic computed tomography angiography (dCTA) in acute ischemic stroke (AIS) patients. The aim of the study was to investigate the associations of delayed-LCVF with clot location, reperfusion status at 24 hours, and 90-days functional outcome in AIS patients who received reperfusion therapy. A prospective cohort of AIS patients treated with intravenous thrombolysis was studied. Groupwise comparison, univariate, and multivariate regression analyses were used to study the association of delayed-LCVF with clot location and clinical outcomes. Of 93 patients (mean age = 72 ± 12 years) with hemispheric AIS included in the study, 46 (49%) demonstrated delayed-LCVF. Patients with delayed-LCVF demonstrated a significantly higher proportion of proximal occlusion (72% vs 13%, P =< 0.0001), and poor reperfusion at 24 hours (41% vs 11%, P = 0.001). The proportion of poor functional outcome at 90 days was not significantly different (22/56 (48%) vs 17/61 (36%), P = 0.297). The appearance of delayed-LCVF on baseline dCTA may be a surrogate for large vessel occlusion, and an early marker for poor 24-hour angiographic reperfusion.
format Online
Article
Text
id pubmed-5137111
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-51371112017-01-27 Association of Cortical Vein Filling with Clot Location and Clinical Outcomes in Acute Ischaemic Stroke Patients Bhaskar, Sonu Bivard, Andrew Stanwell, Peter Attia, John R. Parsons, Mark Nilsson, Michael Levi, Christopher Sci Rep Article Delay in cortical vein filling during the late-venous phase (delayed-LCVF) is characterized by opacification of cerebral veins despite contrast clearance from contralateral veins on dynamic computed tomography angiography (dCTA) in acute ischemic stroke (AIS) patients. The aim of the study was to investigate the associations of delayed-LCVF with clot location, reperfusion status at 24 hours, and 90-days functional outcome in AIS patients who received reperfusion therapy. A prospective cohort of AIS patients treated with intravenous thrombolysis was studied. Groupwise comparison, univariate, and multivariate regression analyses were used to study the association of delayed-LCVF with clot location and clinical outcomes. Of 93 patients (mean age = 72 ± 12 years) with hemispheric AIS included in the study, 46 (49%) demonstrated delayed-LCVF. Patients with delayed-LCVF demonstrated a significantly higher proportion of proximal occlusion (72% vs 13%, P =< 0.0001), and poor reperfusion at 24 hours (41% vs 11%, P = 0.001). The proportion of poor functional outcome at 90 days was not significantly different (22/56 (48%) vs 17/61 (36%), P = 0.297). The appearance of delayed-LCVF on baseline dCTA may be a surrogate for large vessel occlusion, and an early marker for poor 24-hour angiographic reperfusion. Nature Publishing Group 2016-12-05 /pmc/articles/PMC5137111/ /pubmed/27917948 http://dx.doi.org/10.1038/srep38525 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Bhaskar, Sonu
Bivard, Andrew
Stanwell, Peter
Attia, John R.
Parsons, Mark
Nilsson, Michael
Levi, Christopher
Association of Cortical Vein Filling with Clot Location and Clinical Outcomes in Acute Ischaemic Stroke Patients
title Association of Cortical Vein Filling with Clot Location and Clinical Outcomes in Acute Ischaemic Stroke Patients
title_full Association of Cortical Vein Filling with Clot Location and Clinical Outcomes in Acute Ischaemic Stroke Patients
title_fullStr Association of Cortical Vein Filling with Clot Location and Clinical Outcomes in Acute Ischaemic Stroke Patients
title_full_unstemmed Association of Cortical Vein Filling with Clot Location and Clinical Outcomes in Acute Ischaemic Stroke Patients
title_short Association of Cortical Vein Filling with Clot Location and Clinical Outcomes in Acute Ischaemic Stroke Patients
title_sort association of cortical vein filling with clot location and clinical outcomes in acute ischaemic stroke patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137111/
https://www.ncbi.nlm.nih.gov/pubmed/27917948
http://dx.doi.org/10.1038/srep38525
work_keys_str_mv AT bhaskarsonu associationofcorticalveinfillingwithclotlocationandclinicaloutcomesinacuteischaemicstrokepatients
AT bivardandrew associationofcorticalveinfillingwithclotlocationandclinicaloutcomesinacuteischaemicstrokepatients
AT stanwellpeter associationofcorticalveinfillingwithclotlocationandclinicaloutcomesinacuteischaemicstrokepatients
AT attiajohnr associationofcorticalveinfillingwithclotlocationandclinicaloutcomesinacuteischaemicstrokepatients
AT parsonsmark associationofcorticalveinfillingwithclotlocationandclinicaloutcomesinacuteischaemicstrokepatients
AT nilssonmichael associationofcorticalveinfillingwithclotlocationandclinicaloutcomesinacuteischaemicstrokepatients
AT levichristopher associationofcorticalveinfillingwithclotlocationandclinicaloutcomesinacuteischaemicstrokepatients