Sirtuins in metabolism, DNA repair and cancer

The mammalian sirtuin family has attracted tremendous attention over the past few years as stress adaptors and post-translational modifier. They have involved in diverse cellular processes including DNA repair, energy metabolism, and tumorigenesis. Notably, genomic instability and metabolic reprogra...

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Autores principales: Mei, Zhen, Zhang, Xian, Yi, Jiarong, Huang, Junjie, He, Jian, Tao, Yongguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137222/
https://www.ncbi.nlm.nih.gov/pubmed/27916001
http://dx.doi.org/10.1186/s13046-016-0461-5
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author Mei, Zhen
Zhang, Xian
Yi, Jiarong
Huang, Junjie
He, Jian
Tao, Yongguang
author_facet Mei, Zhen
Zhang, Xian
Yi, Jiarong
Huang, Junjie
He, Jian
Tao, Yongguang
author_sort Mei, Zhen
collection PubMed
description The mammalian sirtuin family has attracted tremendous attention over the past few years as stress adaptors and post-translational modifier. They have involved in diverse cellular processes including DNA repair, energy metabolism, and tumorigenesis. Notably, genomic instability and metabolic reprogramming are two of characteristic hallmarks in cancer. In this review, we summarize current knowledge on the functions of sirtuins mainly regarding DNA repair and energy metabolism, and further discuss the implication of sirtuins in cancer specifically by regulating genome integrity and cancer-related metabolism.
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spelling pubmed-51372222016-12-15 Sirtuins in metabolism, DNA repair and cancer Mei, Zhen Zhang, Xian Yi, Jiarong Huang, Junjie He, Jian Tao, Yongguang J Exp Clin Cancer Res Review The mammalian sirtuin family has attracted tremendous attention over the past few years as stress adaptors and post-translational modifier. They have involved in diverse cellular processes including DNA repair, energy metabolism, and tumorigenesis. Notably, genomic instability and metabolic reprogramming are two of characteristic hallmarks in cancer. In this review, we summarize current knowledge on the functions of sirtuins mainly regarding DNA repair and energy metabolism, and further discuss the implication of sirtuins in cancer specifically by regulating genome integrity and cancer-related metabolism. BioMed Central 2016-12-05 /pmc/articles/PMC5137222/ /pubmed/27916001 http://dx.doi.org/10.1186/s13046-016-0461-5 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Mei, Zhen
Zhang, Xian
Yi, Jiarong
Huang, Junjie
He, Jian
Tao, Yongguang
Sirtuins in metabolism, DNA repair and cancer
title Sirtuins in metabolism, DNA repair and cancer
title_full Sirtuins in metabolism, DNA repair and cancer
title_fullStr Sirtuins in metabolism, DNA repair and cancer
title_full_unstemmed Sirtuins in metabolism, DNA repair and cancer
title_short Sirtuins in metabolism, DNA repair and cancer
title_sort sirtuins in metabolism, dna repair and cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137222/
https://www.ncbi.nlm.nih.gov/pubmed/27916001
http://dx.doi.org/10.1186/s13046-016-0461-5
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