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Electrical stimulation of prelymbic with different currents intensities on morphine induced spatial memory deficit in rats
BACKGROUND: The medial prefrontal cortex (mPFC) is a part of brain reward system involved in cognitive functions such as learning and memory. Previous studies showed that electrical stimulation of prelymbic produced different effects on morphine-induced condition place preference. In this study, we...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137232/ https://www.ncbi.nlm.nih.gov/pubmed/27995105 http://dx.doi.org/10.4103/2277-9175.192730 |
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author | Mehdipour, Shima Alaei, Hojjatallah Reisi, Parham Marghmaleki, Vajihe Saedi |
author_facet | Mehdipour, Shima Alaei, Hojjatallah Reisi, Parham Marghmaleki, Vajihe Saedi |
author_sort | Mehdipour, Shima |
collection | PubMed |
description | BACKGROUND: The medial prefrontal cortex (mPFC) is a part of brain reward system involved in cognitive functions such as learning and memory. Previous studies showed that electrical stimulation of prelymbic produced different effects on morphine-induced condition place preference. In this study, we investigated the electrical stimulation with different current intensities on spatial memory in rats. MATERIALS AND METHODS: In this study, male Wister rats weighing approximately 200–300 g were used. The effect of prelymbic electrical stimulation with 25 and 150 μA currents intensities in healthy and addicted rats on spatial memory was studied. Spatial memory was investigated using the Morris water maze test in addicted rats after 9 days of electrical stimulation. RESULTS: Our findings have shown that morphine reduces the memory and learning, whereas the present results indicated that electrical stimulation of prelymbic area with current intensity of the 25 μA shortened the time and distance to reach to platform that indicated improvement in spatial memory on addicted rats. Whereas the electrical stimulation of prelymbic area with the current intensity of 150 μA has special weakening effects on spatial memory and prolongs the time and distance to reach the platform. CONCLUSIONS: The electrical stimulations of prelymbic with 25 μA current intensity improved the spatial memory in addicted rats while with 150 μA current intensity weakened spatial memory in rats. It is possible that increase in the release of some neurotransmitters reverses the effect of morphine on spatial memory. |
format | Online Article Text |
id | pubmed-5137232 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-51372322016-12-19 Electrical stimulation of prelymbic with different currents intensities on morphine induced spatial memory deficit in rats Mehdipour, Shima Alaei, Hojjatallah Reisi, Parham Marghmaleki, Vajihe Saedi Adv Biomed Res Original Article BACKGROUND: The medial prefrontal cortex (mPFC) is a part of brain reward system involved in cognitive functions such as learning and memory. Previous studies showed that electrical stimulation of prelymbic produced different effects on morphine-induced condition place preference. In this study, we investigated the electrical stimulation with different current intensities on spatial memory in rats. MATERIALS AND METHODS: In this study, male Wister rats weighing approximately 200–300 g were used. The effect of prelymbic electrical stimulation with 25 and 150 μA currents intensities in healthy and addicted rats on spatial memory was studied. Spatial memory was investigated using the Morris water maze test in addicted rats after 9 days of electrical stimulation. RESULTS: Our findings have shown that morphine reduces the memory and learning, whereas the present results indicated that electrical stimulation of prelymbic area with current intensity of the 25 μA shortened the time and distance to reach to platform that indicated improvement in spatial memory on addicted rats. Whereas the electrical stimulation of prelymbic area with the current intensity of 150 μA has special weakening effects on spatial memory and prolongs the time and distance to reach the platform. CONCLUSIONS: The electrical stimulations of prelymbic with 25 μA current intensity improved the spatial memory in addicted rats while with 150 μA current intensity weakened spatial memory in rats. It is possible that increase in the release of some neurotransmitters reverses the effect of morphine on spatial memory. Medknow Publications & Media Pvt Ltd 2016-10-26 /pmc/articles/PMC5137232/ /pubmed/27995105 http://dx.doi.org/10.4103/2277-9175.192730 Text en Copyright: © 2016 Advanced Biomedical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Mehdipour, Shima Alaei, Hojjatallah Reisi, Parham Marghmaleki, Vajihe Saedi Electrical stimulation of prelymbic with different currents intensities on morphine induced spatial memory deficit in rats |
title | Electrical stimulation of prelymbic with different currents intensities on morphine induced spatial memory deficit in rats |
title_full | Electrical stimulation of prelymbic with different currents intensities on morphine induced spatial memory deficit in rats |
title_fullStr | Electrical stimulation of prelymbic with different currents intensities on morphine induced spatial memory deficit in rats |
title_full_unstemmed | Electrical stimulation of prelymbic with different currents intensities on morphine induced spatial memory deficit in rats |
title_short | Electrical stimulation of prelymbic with different currents intensities on morphine induced spatial memory deficit in rats |
title_sort | electrical stimulation of prelymbic with different currents intensities on morphine induced spatial memory deficit in rats |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137232/ https://www.ncbi.nlm.nih.gov/pubmed/27995105 http://dx.doi.org/10.4103/2277-9175.192730 |
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