Extracellular vesicle-associated Aβ mediates trans-neuronal bioenergetic and Ca(2+)-handling deficits in Alzheimer’s disease models

Alzheimer’s disease (AD) is an age-related neurodegenerative disorder in which aggregation-prone neurotoxic amyloid β-peptide (Aβ) accumulates in the brain. Extracellular vesicles (EVs), including exosomes, are small 50–150 nm membrane vesicles that have recently been implicated in the prion-like sp...

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Detalles Bibliográficos
Autores principales: Eitan, Erez, Hutchison, Emmette R, Marosi, Krisztina, Comotto, James, Mustapic, Maja, Nigam, Saket M, Suire, Caitlin, Maharana, Chinmoyee, Jicha, Gregory A, Liu, Dong, Machairaki, Vasiliki, Witwer, Kenneth W, Kapogiannis, Dimitrios, Mattson, Mark P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137253/
https://www.ncbi.nlm.nih.gov/pubmed/27928512
http://dx.doi.org/10.1038/npjamd.2016.19

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