Down-Regulation of Hippocampal Genes Regulating Dopaminergic, GABAergic, and Glutamatergic Function Following Combined Neonatal Phencyclidine and Post-Weaning Social Isolation of Rats as a Neurodevelopmental Model for Schizophrenia

BACKGROUND: Dysfunction of dopaminergic, GABAergic, and glutamatergic function underlies many core symptoms of schizophrenia. Combined neonatal injection of the N-methyl-D-aspartate (NMDA) receptor antagonist, phencyclidine (PCP), and post-weaning social isolation of rats produces a behavioral syndr...

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Detalles Bibliográficos
Autores principales: Gaskin, Philip LR, Toledo-Rodriguez, Maria, Alexander, Stephen PH, Fone, Kevin CF
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Regular Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137279/
https://www.ncbi.nlm.nih.gov/pubmed/27382048
http://dx.doi.org/10.1093/ijnp/pyw062

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