Perlman syndrome nuclease DIS3L2 controls cytoplasmic non-coding RNAs and provides surveillance pathway for maturing snRNAs

The exosome-independent exoribonuclease DIS3L2 is mutated in Perlman syndrome. Here, we used extensive global transcriptomic and targeted biochemical analyses to identify novel DIS3L2 substrates in human cells. We show that DIS3L2 regulates pol II transcripts, comprising selected canonical and histo...

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Detalles Bibliográficos
Autores principales: Łabno, Anna, Warkocki, Zbigniew, Kuliński, Tomasz, Krawczyk, Paweł Szczepan, Bijata, Krystian, Tomecki, Rafał, Dziembowski, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137419/
https://www.ncbi.nlm.nih.gov/pubmed/27431325
http://dx.doi.org/10.1093/nar/gkw649

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