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Cytoplasmic Drosha activity generated by alternative splicing

RNase III enzyme Drosha interacts with DGCR8 to form the Microprocessor, initiating canonical microRNA (miRNA) maturation in the nucleus. Here, we re-evaluated where Drosha functions in cells using Drosha and/or DGCR8 knock out (KO) cells and cleavage reporters. Interestingly, a truncated Drosha mut...

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Detalles Bibliográficos
Autores principales:	Dai, Lisheng, Chen, Kevin, Youngren, Brenda, Kulina, Julia, Yang, Acong, Guo, Zhengyu, Li, Jin, Yu, Peng, Gu, Shuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137420/ https://www.ncbi.nlm.nih.gov/pubmed/27471035 http://dx.doi.org/10.1093/nar/gkw668

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