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DNA gyrase with a single catalytic tyrosine can catalyze DNA supercoiling by a nicking-closing mechanism

The topological state of DNA is important for replication, recombination and transcription, and is regulated in vivo by DNA topoisomerases. Gyrase introduces negative supercoils into DNA at the expense of ATP hydrolysis. It is the accepted view that gyrase achieves supercoiling by a strand passage m...

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Detalles Bibliográficos
Autores principales:	Gubaev, Airat, Weidlich, Daniela, Klostermeier, Dagmar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137430/ https://www.ncbi.nlm.nih.gov/pubmed/27557712 http://dx.doi.org/10.1093/nar/gkw740

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