DNA damage response curtails detrimental replication stress and chromosomal instability induced by the dietary carcinogen PhIP

PhIP is an abundant heterocyclic aromatic amine (HCA) and important dietary carcinogen. Following metabolic activation, PhIP causes bulky DNA lesions at the C8-position of guanine. Although C8-PhIP-dG adducts are mutagenic, their interference with the DNA replication machinery and the elicited DNA d...

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Detalles Bibliográficos
Autores principales: Mimmler, Maximilian, Peter, Simon, Kraus, Alexander, Stroh, Svenja, Nikolova, Teodora, Seiwert, Nina, Hasselwander, Solveig, Neitzel, Carina, Haub, Jessica, Monien, Bernhard H., Nicken, Petra, Steinberg, Pablo, Shay, Jerry W., Kaina, Bernd, Fahrer, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137439/
https://www.ncbi.nlm.nih.gov/pubmed/27599846
http://dx.doi.org/10.1093/nar/gkw791

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