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Crystal structure of endonuclease G in complex with DNA reveals how it nonspecifically degrades DNA as a homodimer

Endonuclease G (EndoG) is an evolutionarily conserved mitochondrial protein in eukaryotes that digests nucleus chromosomal DNA during apoptosis and paternal mitochondrial DNA during embryogenesis. Under oxidative stress, homodimeric EndoG becomes oxidized and converts to monomers with diminished nuc...

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Detalles Bibliográficos
Autores principales:	Lin, Jason L. J., Wu, Chyuan-Chuan, Yang, Wei-Zen, Yuan, Hanna S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137453/ https://www.ncbi.nlm.nih.gov/pubmed/27738134 http://dx.doi.org/10.1093/nar/gkw931

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