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Crystal structure of vilazodone hydro­chloride methanol monosolvate

In the title compound, C(26)H(28)N(5)O(2) (+)·Cl(−)·CH(3)OH {systematic name: 4-(2-carbamoyl-1-benzo­furan-5-yl)-1-[4-(5-cyano-1H-indol-3-yl)but­yl]piperazin-1-ium chloride methanol monosolvate}, the protonated piperazine ring adopts a chair conformation. The indole ring plane is nearly perpendicula...

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Detalles Bibliográficos
Autores principales: Hu, Xiu-Rong, Ye, Jia-Li, Gu, Jian-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137608/
https://www.ncbi.nlm.nih.gov/pubmed/27980830
http://dx.doi.org/10.1107/S2056989016017734
Descripción
Sumario:In the title compound, C(26)H(28)N(5)O(2) (+)·Cl(−)·CH(3)OH {systematic name: 4-(2-carbamoyl-1-benzo­furan-5-yl)-1-[4-(5-cyano-1H-indol-3-yl)but­yl]piperazin-1-ium chloride methanol monosolvate}, the protonated piperazine ring adopts a chair conformation. The indole ring plane is nearly perpendicular to the benzo­furan ring system, with a dihedral angle of 85.77 (2)°. In the crystal, the organic cations, Cl(−) anions and methanol solvent mol­ecules are linked by classical N—H⋯O and N—H⋯Cl hydrogen bonds, and weak C—H⋯O and C—H⋯π inter­actions into a three-dimensional supra­molecular architecture.