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Normalized vitamin D metabolite concentrations are better correlated to pharmacological effects than measured concentrations
BACKGROUND: Vitamin D deficiency has been associated with a multitude of diseases, ranging from fractures to cancer. Nearly 99% of vitamin D metabolites are bound to proteins, altering the relationship between concentration and activity. METHODS & RESULTS: Normalized concentrations were calculat...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Future Science Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137860/ https://www.ncbi.nlm.nih.gov/pubmed/28031931 http://dx.doi.org/10.4155/fso.15.83 |
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author | Mason, Darius Donabella, Paul J Nnani, Daryl Musteata, Florin Marcel |
author_facet | Mason, Darius Donabella, Paul J Nnani, Daryl Musteata, Florin Marcel |
author_sort | Mason, Darius |
collection | PubMed |
description | BACKGROUND: Vitamin D deficiency has been associated with a multitude of diseases, ranging from fractures to cancer. Nearly 99% of vitamin D metabolites are bound to proteins, altering the relationship between concentration and activity. METHODS & RESULTS: Normalized concentrations were calculated and validated using published data regarding the correlation of 25-hydroxyvitamin D with bone mineral density. In addition, healthy and kidney disease subjects were recruited for preliminary investigations. Use of the normalizing equations resulted in statistically significant improvements in the relationship between vitamin D metabolites and several markers of health status. CONCLUSION: Normalized concentrations are similar to clinically reported values and are easier to interpret than free or bioavailable concentrations, since their values match the range of measured total concentrations. [Image: see text] |
format | Online Article Text |
id | pubmed-5137860 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Future Science Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-51378602016-12-28 Normalized vitamin D metabolite concentrations are better correlated to pharmacological effects than measured concentrations Mason, Darius Donabella, Paul J Nnani, Daryl Musteata, Florin Marcel Future Sci OA Research Article BACKGROUND: Vitamin D deficiency has been associated with a multitude of diseases, ranging from fractures to cancer. Nearly 99% of vitamin D metabolites are bound to proteins, altering the relationship between concentration and activity. METHODS & RESULTS: Normalized concentrations were calculated and validated using published data regarding the correlation of 25-hydroxyvitamin D with bone mineral density. In addition, healthy and kidney disease subjects were recruited for preliminary investigations. Use of the normalizing equations resulted in statistically significant improvements in the relationship between vitamin D metabolites and several markers of health status. CONCLUSION: Normalized concentrations are similar to clinically reported values and are easier to interpret than free or bioavailable concentrations, since their values match the range of measured total concentrations. [Image: see text] Future Science Ltd 2015-11-30 /pmc/articles/PMC5137860/ /pubmed/28031931 http://dx.doi.org/10.4155/fso.15.83 Text en © Florin Marcel Musteata This work is licensed under a Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/) |
spellingShingle | Research Article Mason, Darius Donabella, Paul J Nnani, Daryl Musteata, Florin Marcel Normalized vitamin D metabolite concentrations are better correlated to pharmacological effects than measured concentrations |
title | Normalized vitamin D metabolite concentrations are better correlated to pharmacological effects than measured concentrations |
title_full | Normalized vitamin D metabolite concentrations are better correlated to pharmacological effects than measured concentrations |
title_fullStr | Normalized vitamin D metabolite concentrations are better correlated to pharmacological effects than measured concentrations |
title_full_unstemmed | Normalized vitamin D metabolite concentrations are better correlated to pharmacological effects than measured concentrations |
title_short | Normalized vitamin D metabolite concentrations are better correlated to pharmacological effects than measured concentrations |
title_sort | normalized vitamin d metabolite concentrations are better correlated to pharmacological effects than measured concentrations |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137860/ https://www.ncbi.nlm.nih.gov/pubmed/28031931 http://dx.doi.org/10.4155/fso.15.83 |
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