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Normalized vitamin D metabolite concentrations are better correlated to pharmacological effects than measured concentrations

BACKGROUND: Vitamin D deficiency has been associated with a multitude of diseases, ranging from fractures to cancer. Nearly 99% of vitamin D metabolites are bound to proteins, altering the relationship between concentration and activity. METHODS & RESULTS: Normalized concentrations were calculat...

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Detalles Bibliográficos
Autores principales: Mason, Darius, Donabella, Paul J, Nnani, Daryl, Musteata, Florin Marcel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137860/
https://www.ncbi.nlm.nih.gov/pubmed/28031931
http://dx.doi.org/10.4155/fso.15.83
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author Mason, Darius
Donabella, Paul J
Nnani, Daryl
Musteata, Florin Marcel
author_facet Mason, Darius
Donabella, Paul J
Nnani, Daryl
Musteata, Florin Marcel
author_sort Mason, Darius
collection PubMed
description BACKGROUND: Vitamin D deficiency has been associated with a multitude of diseases, ranging from fractures to cancer. Nearly 99% of vitamin D metabolites are bound to proteins, altering the relationship between concentration and activity. METHODS & RESULTS: Normalized concentrations were calculated and validated using published data regarding the correlation of 25-hydroxyvitamin D with bone mineral density. In addition, healthy and kidney disease subjects were recruited for preliminary investigations. Use of the normalizing equations resulted in statistically significant improvements in the relationship between vitamin D metabolites and several markers of health status. CONCLUSION: Normalized concentrations are similar to clinically reported values and are easier to interpret than free or bioavailable concentrations, since their values match the range of measured total concentrations. [Image: see text]
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spelling pubmed-51378602016-12-28 Normalized vitamin D metabolite concentrations are better correlated to pharmacological effects than measured concentrations Mason, Darius Donabella, Paul J Nnani, Daryl Musteata, Florin Marcel Future Sci OA Research Article BACKGROUND: Vitamin D deficiency has been associated with a multitude of diseases, ranging from fractures to cancer. Nearly 99% of vitamin D metabolites are bound to proteins, altering the relationship between concentration and activity. METHODS & RESULTS: Normalized concentrations were calculated and validated using published data regarding the correlation of 25-hydroxyvitamin D with bone mineral density. In addition, healthy and kidney disease subjects were recruited for preliminary investigations. Use of the normalizing equations resulted in statistically significant improvements in the relationship between vitamin D metabolites and several markers of health status. CONCLUSION: Normalized concentrations are similar to clinically reported values and are easier to interpret than free or bioavailable concentrations, since their values match the range of measured total concentrations. [Image: see text] Future Science Ltd 2015-11-30 /pmc/articles/PMC5137860/ /pubmed/28031931 http://dx.doi.org/10.4155/fso.15.83 Text en © Florin Marcel Musteata This work is licensed under a Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/)
spellingShingle Research Article
Mason, Darius
Donabella, Paul J
Nnani, Daryl
Musteata, Florin Marcel
Normalized vitamin D metabolite concentrations are better correlated to pharmacological effects than measured concentrations
title Normalized vitamin D metabolite concentrations are better correlated to pharmacological effects than measured concentrations
title_full Normalized vitamin D metabolite concentrations are better correlated to pharmacological effects than measured concentrations
title_fullStr Normalized vitamin D metabolite concentrations are better correlated to pharmacological effects than measured concentrations
title_full_unstemmed Normalized vitamin D metabolite concentrations are better correlated to pharmacological effects than measured concentrations
title_short Normalized vitamin D metabolite concentrations are better correlated to pharmacological effects than measured concentrations
title_sort normalized vitamin d metabolite concentrations are better correlated to pharmacological effects than measured concentrations
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137860/
https://www.ncbi.nlm.nih.gov/pubmed/28031931
http://dx.doi.org/10.4155/fso.15.83
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