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Conducting polymer-based multilayer films for instructive biomaterial coatings

AIM: To demonstrate the design, fabrication and testing of conformable conducting biomaterials that encourage cell alignment. MATERIALS & METHODS: Thin conducting composite biomaterials based on multilayer films of poly(3.4-ethylenedioxythiophene) derivatives, chitosan and gelatin were prepared...

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Detalles Bibliográficos
Autores principales: Hardy, John G, Li, Hetian, Chow, Jacqueline K, Geissler, Sydney A, McElroy, Austin B, Nguy, Lindsey, Hernandez, Derek S, Schmidt, Christine E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137882/
https://www.ncbi.nlm.nih.gov/pubmed/28031928
http://dx.doi.org/10.4155/fso.15.79
Descripción
Sumario:AIM: To demonstrate the design, fabrication and testing of conformable conducting biomaterials that encourage cell alignment. MATERIALS & METHODS: Thin conducting composite biomaterials based on multilayer films of poly(3.4-ethylenedioxythiophene) derivatives, chitosan and gelatin were prepared in a layer-by-layer fashion. Fibroblasts were observed with fluorescence microscopy and their alignment (relative to the dipping direction and direction of electrical current passed through the films) was determined using ImageJ. RESULTS: Fibroblasts adhered to and proliferated on the films. Fibroblasts aligned with the dipping direction used during film preparation and this was enhanced by a DC current. CONCLUSION: We report the preparation of conducting polymer-based films that enhance the alignment of fibroblasts on their surface which is an important feature of a variety of tissues. [Image: see text]