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Conducting polymer-based multilayer films for instructive biomaterial coatings
AIM: To demonstrate the design, fabrication and testing of conformable conducting biomaterials that encourage cell alignment. MATERIALS & METHODS: Thin conducting composite biomaterials based on multilayer films of poly(3.4-ethylenedioxythiophene) derivatives, chitosan and gelatin were prepared...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Future Science Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137882/ https://www.ncbi.nlm.nih.gov/pubmed/28031928 http://dx.doi.org/10.4155/fso.15.79 |
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author | Hardy, John G Li, Hetian Chow, Jacqueline K Geissler, Sydney A McElroy, Austin B Nguy, Lindsey Hernandez, Derek S Schmidt, Christine E |
author_facet | Hardy, John G Li, Hetian Chow, Jacqueline K Geissler, Sydney A McElroy, Austin B Nguy, Lindsey Hernandez, Derek S Schmidt, Christine E |
author_sort | Hardy, John G |
collection | PubMed |
description | AIM: To demonstrate the design, fabrication and testing of conformable conducting biomaterials that encourage cell alignment. MATERIALS & METHODS: Thin conducting composite biomaterials based on multilayer films of poly(3.4-ethylenedioxythiophene) derivatives, chitosan and gelatin were prepared in a layer-by-layer fashion. Fibroblasts were observed with fluorescence microscopy and their alignment (relative to the dipping direction and direction of electrical current passed through the films) was determined using ImageJ. RESULTS: Fibroblasts adhered to and proliferated on the films. Fibroblasts aligned with the dipping direction used during film preparation and this was enhanced by a DC current. CONCLUSION: We report the preparation of conducting polymer-based films that enhance the alignment of fibroblasts on their surface which is an important feature of a variety of tissues. [Image: see text] |
format | Online Article Text |
id | pubmed-5137882 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Future Science Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-51378822016-12-28 Conducting polymer-based multilayer films for instructive biomaterial coatings Hardy, John G Li, Hetian Chow, Jacqueline K Geissler, Sydney A McElroy, Austin B Nguy, Lindsey Hernandez, Derek S Schmidt, Christine E Future Sci OA Preliminary Communication AIM: To demonstrate the design, fabrication and testing of conformable conducting biomaterials that encourage cell alignment. MATERIALS & METHODS: Thin conducting composite biomaterials based on multilayer films of poly(3.4-ethylenedioxythiophene) derivatives, chitosan and gelatin were prepared in a layer-by-layer fashion. Fibroblasts were observed with fluorescence microscopy and their alignment (relative to the dipping direction and direction of electrical current passed through the films) was determined using ImageJ. RESULTS: Fibroblasts adhered to and proliferated on the films. Fibroblasts aligned with the dipping direction used during film preparation and this was enhanced by a DC current. CONCLUSION: We report the preparation of conducting polymer-based films that enhance the alignment of fibroblasts on their surface which is an important feature of a variety of tissues. [Image: see text] Future Science Ltd 2015-11-02 /pmc/articles/PMC5137882/ /pubmed/28031928 http://dx.doi.org/10.4155/fso.15.79 Text en © John George Hardy This work is licensed under a Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/) |
spellingShingle | Preliminary Communication Hardy, John G Li, Hetian Chow, Jacqueline K Geissler, Sydney A McElroy, Austin B Nguy, Lindsey Hernandez, Derek S Schmidt, Christine E Conducting polymer-based multilayer films for instructive biomaterial coatings |
title | Conducting polymer-based multilayer films for instructive biomaterial coatings |
title_full | Conducting polymer-based multilayer films for instructive biomaterial coatings |
title_fullStr | Conducting polymer-based multilayer films for instructive biomaterial coatings |
title_full_unstemmed | Conducting polymer-based multilayer films for instructive biomaterial coatings |
title_short | Conducting polymer-based multilayer films for instructive biomaterial coatings |
title_sort | conducting polymer-based multilayer films for instructive biomaterial coatings |
topic | Preliminary Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137882/ https://www.ncbi.nlm.nih.gov/pubmed/28031928 http://dx.doi.org/10.4155/fso.15.79 |
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